Differences in Regional Brain Activities during Memory Acquisition Depending on Individual Working Memory Capacity
Differences in Regional Brain Activities during Memory Acquisition Depending on Individual Working Memory Capacity
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DOI：
10.14326/abe.8.23
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发表时间：
2019
影响因子：
1
通讯作者：
H. Gan;Tatsuya Suzuki;K. Yokosawa;Y. Ono
中科院分区：
文献类型：
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作者：
H. Gan;Tatsuya Suzuki;K. Yokosawa;Y. Ono
即使在健康的年轻人中，个体的回忆记忆能力也有很大的差异。然而，不同的记忆能力背后的大脑回路的差异还没有得到充分的研究。我们从43名健康的年轻人中获得了脑电图测量结果，同时进行了一项要求很高的工作记忆任务，并研究了与不同水平的记忆表现有关的区域皮层活动的变化。记忆任务包括在编码期间向参与者顺序呈现七个箭头图片，然后要求参与者在检索期间回忆序列中一个箭头的方向。我们根据加权分层分组法将参与者分为高、中、低三组。采用多稀疏先验方法对高、低成绩组的局部脑活动进行源定位，并通过非参数排列检验确定组间差异。我们的研究结果表明，记忆力较高的参与者表现出更广泛的皮质活动分布，包括前额叶和顶后皮质，而记忆力较低的参与者只表现出稳定的枕叶区域激活。这些结果暗示了选择性注意的重要性，以达到最佳的个人工作记忆性能。此外，我们建议的潜在作用的角回之间的相互作用的前额叶和后部区域的管理刺激流和信号控制。未来的工作应该集中在进行更彻底的连接分析，以调查皮层激活与个人工作记忆性能的关系。
Individual capacity of recall memory varies greatly even among healthy young adults. Nevertheless, the difference in brain circuitry underlying varied memory capacity has yet to be fully investigated. We acquired electroencephalographic measurements from 43 healthy young adults while performing a demanding working memory task and studied the changes in regional cortical activity in relation to different levels of memory performance. The memory task involved sequentially presenting seven arrow pictures to a participant during the encoding period, who was then asked to recall the direction of one of the arrows in the sequence within the retrieval period. We divided the participants into three groups of high, intermediate, and low performance based on the weighted hierarchical grouping method. Regional brain activities were source-localized using multiple sparse priors method in the highand low-performance groups, and group differences were determined by non-parametric permutation tests. Our ndings showed that participants with higher memory performance exhibited wider distribution of cortical activity including the prefrontal and parieto-posterior cortices, whereas lower performance participants only exhibited stable activations across occipital regions. The results implied the importance of selective attention in order to attain optimal individual working memory performance. Furthermore, we suggest the potential role of the angular gyrus as an interplay between the prefrontal and posterior regions for the management of stimulus ow and signal control. Future works should focus on conducting more thorough connectivity analysis to investigate the relationship of cortical activations with individual working memory performance.