Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.
Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.
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DOI：
10.4049/jimmunol.140.1.52
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发表时间：
1988-01
影响因子：
4.4
通讯作者：
B. J. Miller;M. Appel;J. O'neil;L. Wicker
中科院分区：
文献类型：
--
作者：
B. J. Miller;M. Appel;J. O'neil;L. Wicker
非肥胖糖尿病小鼠是自发性 I 型糖尿病的模型。通过使用从糖尿病供体获得的脾细胞或脾 T 细胞的过继转移，可以在年轻的、受辐射的非肥胖糖尿病小鼠中诱导糖尿病。这项研究表明，过继转移系统中糖尿病的诱导依赖于 T 细胞的 L3T4+ 和 Lyt-2+ 亚群。当这些 T 细胞亚群被过继转移给年轻的、受辐射的接受者时，它们都不会单独介导严重胰岛素炎或糖尿病的发展。此外，我们还表明，为了转移糖尿病，L3T4+ 和 Lyt-2+ 子集必须从糖尿病供体获得；这两个子集都不能用从年轻的非糖尿病捐献者获得的细胞替代。
The nonobese diabetic mouse is a model of spontaneous type I diabetes mellitus. It is possible to induce diabetes in young, irradiated nonobese diabetic mice by using adoptive transfer of splenocytes or splenic T cells obtained from diabetic donors. This study demonstrates that the induction of diabetes in the adoptive transfer system is dependent on both the L3T4+ and Lyt-2+ subsets of T cells. Neither of these T cell subsets alone mediates the development of severe insulitis or diabetes when adoptively transferred to young, irradiated recipients. In addition, we show that both the L3T4+ and Lyt-2+ subsets must be obtained from diabetic donors in order to transfer diabetes; neither subset can be replaced with cells obtained from young, nondiabetic donors.