SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY OF HYGROMYCIN-A ANALOGS MODIFIED AT THE C4' ARYL POSITION
SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY OF HYGROMYCIN-A ANALOGS MODIFIED AT THE C4' ARYL POSITION
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DOI：
10.1016/s0960-894x(00)80012-8
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发表时间：
1993-08-01
影响因子：
2.7
通讯作者：
WERNER, KM
中科院分区：
文献类型：
--
作者：
JAYNES, BH;COOPER, CB;WERNER, KM
描述了多种潮霉素A类似物，其含有天然糖的修饰或替代。据报道，对丝氨酸（密螺旋体）猪痢疾（一种重要的动物健康病原体）的抗菌活性表明，小的亲脂性 C4' 取代基可作为潮霉素 A 类中有用的糖替代品。
A variety of hygromycin A analogs are described which contain modifications of or replacements for the natural sugar. Antibacterial activities against Serpulina (Treponema) hyodysenteriae, an important animal health pathogen, are reported and indicate that small lipophilic C4' substituents serve as useful sugar surrogates in the hygromycin A class.