Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development
Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development
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DOI：
10.1182/blood-2009-07-232694
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发表时间：
2010-01-21
期刊：
影响因子：
20.3
通讯作者：
Hu, Hui
中科院分区：
文献类型：
--
作者：
Feng, Xiaoming;Ippolito, Gregory C.;Hu, Hui
需要适当的胸腺细胞发育以建立T细胞中枢耐受性并产生幼稚T细胞，这两者对于T细胞稳态和功能性免疫系统都是必不可少的。在这里，我们证明了转录因子Foxp 1的丢失导致T细胞的异常发育。Foxp 1缺陷型单阳性胸腺细胞在胸腺中过早获得活化表型，而不是产生幼稚T细胞，并导致外周CD 4（+）T和CD 8（+）T细胞的产生，这些细胞表现出活化表型和增加的凋亡，并在T细胞受体结合时容易产生细胞因子。这些结果确定Foxp 1作为胸腺细胞发育和产生静止幼稚T细胞的重要转录调节因子。（血。2010; 115：510-518）
Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8(+) T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells. (Blood. 2010; 115: 510-518)