Chronic pressure overload hypertrophy decreases direct ventricular interaction.
Chronic pressure overload hypertrophy decreases direct ventricular interaction.
复制标题
慢性压力超负荷肥大会降低直接心室相互作用。
DOI：
10.1152/ajpheart.1987.253.2.h347
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Glantz,SA
中科院分区：
文献类型：
--
作者：
Slinker,BK;Chagas,AC;Glantz,SA
我们研究了直接（通过室间隔）和系列（通过肺循环）心室相互作用在向心性左心室肥厚的心脏中的相对作用，通过使用统计模型来分析5只开胸麻醉犬的右心室和左心室压力和尺寸对腔静脉和肺动脉阻塞的瞬态反应。这些犬的左心室存在由3个月肾血管性高血压[左心室峰值压力= 160 +/- 13（SD）mmHg]诱导的中度向心性肥大（质量增加31%）。在实验结束时，我们发现，在确定左心室大小时，直接相互作用的重要性仅为与心脏周围心包的串联相互作用的十分之一。在收缩末期，我们发现在决定左心室大小方面，直接相互作用的重要性约为收缩末期压力-容积关系的五分之一。去除心包降低了直接相互作用的重要性。与正常心脏相比，这些心脏中的直接相互作用不那么重要，这可能是因为隔膜较厚，因此扩张性较小。心室与肥厚直接相互作用的相对重要性的这种变化使正常和肥厚心脏之间的压力-容积关系的比较复杂化。
We studied the relative roles of direct (via the interventricular septum) and series (via the pulmonary circulation) ventricular interaction in hearts with concentric left ventricular hypertrophy by using statistical models to analyze the transient responses in right and left ventricular pressures and dimensions to occlusions of the venae cava and pulmonary artery in five open-chest anesthetized dogs. The left ventricles of these dogs had moderate concentric hypertrophy (31% increase in mass) induced by 3 mo of renovascular hypertension [peak left ventricular pressure = 160 +/- 13 (SD) mmHg]. At end diastole we found that direct interaction was only about one-tenth as important as series interaction in determining left ventricular size with the pericardium around the heart. At end systole we found that direct interaction was about one-fifth as important as the end-systolic pressure-volume relationship in determining left ventricular size. Removing the pericardium decreased the importance of direct interaction. Direct interaction is less important in these hearts than in normal hearts, probably because the septum is thicker and, hence, less distensible. This change in the relative importance of direct ventricular interaction with hypertrophy complicates comparison of pressure-volume relationships between normal and hypertrophied hearts.