PATHOGENESIS OF BACTEREMIA DUE TO PSEUDOMONAS-AERUGINOSA IN CYCLOPHOSPHAMIDE-TREATED MICE AND POTENTIATION OF VIRULENCE OF ENDOGENOUS STREPTOCOCCI
PATHOGENESIS OF BACTEREMIA DUE TO PSEUDOMONAS-AERUGINOSA IN CYCLOPHOSPHAMIDE-TREATED MICE AND POTENTIATION OF VIRULENCE OF ENDOGENOUS STREPTOCOCCI
复制标题
DOI：
10.1093/infdis/137.6.795
复制
发表时间：
1978-01-01
影响因子：
6.4
通讯作者：
BROWNSTEIN, DG
中科院分区：
文献类型：
--
作者：
BROWNSTEIN, DG
在随后的饮用水中给予铜绿假单胞菌期间，在第0天用环磷酰胺处理的小鼠按顺序间隔处死，并使用过氧化物酶标记的抗体和培养技术检查细菌定植和增殖的部位。这些研究与临床和组织病理学变化相协调。第4天在鼻鳞柱连接处和龈沟嵴角质层表面首次检测到细菌抗原。铜绿假单胞菌从这些部位迅速侵入组织并导致菌血症。无下消化道侵犯。内源性基团B β-溶血性链球菌定植并穿透由先前假单胞菌属入侵造成的溃疡。显然，上皮定植是免疫抑制宿主中铜绿假单胞菌引起的菌血症发病机制中的关键事件。由此产生的感染可能为内源性链球菌的入侵和毒力增强提供了一个渠道。
Mice treated with cyclophosphamide on day 0 were killed at sequential intervals during subsequent administration of P. aeruginosa in drinking water and were examined for sites of bacterial colonization and multiplication with use of peroxidase-labeled antibody and culture techniques. These studies were coordinated with those of clinical and histopathologic changes. Bacterial antigen was first detected on day 4 on the surface of nasal squamocolumnar junctions and the stratum corneum of gingival sulci and crests. Invasion of tissue by P. aeruginosa proceeded rapidly from these sites and led to bacteremia. There was no invasion of the lower alimentary canal. Endogenous group B .beta.-hemolytic streptococci colonized and penetrated ulcers created by previous Pseudomonas invasion. Apparently epithelial colonization is the critical event in the pathogenesis of bacteremia due to P. aeruginosa in the immunosuppressed host. The resulting infection may provide a conduit for invasion and enhancement of the virulence of endogenous streptocci.