ASPIRIN AND BLEEDING PEPTIC-ULCERS IN THE ELDERLY
ASPIRIN AND BLEEDING PEPTIC-ULCERS IN THE ELDERLY
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DOI：
10.1136/bmj.297.6659.1311
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发表时间：
1988-11-19
影响因子：
105.7
通讯作者：
LANGMAN, MJS
中科院分区：
文献类型：
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作者：
FAULKNER, G;PRICHARD, P;LANGMAN, MJS
进行了一项病例对照研究，以确定阿司匹林是否具有与非阿司匹林、非甾体抗炎药相似的老年胃溃疡或十二指肠溃疡出血风险。检查了230名60岁及以上出血性溃疡患者以及年龄和性别相匹配的医院和社区对照患者的止痛药摄入量。那些服用阿司匹林的人因溃疡出血住院的可能性要高出两到三倍。这种增加的风险不是由于消化不良服用阿司匹林或同时使用非阿司匹林、非甾体抗炎药所致。对乙酰氨基酚未观察到类似的作用。
A case-control study was performed to determine whether aspirin confers a similar risk of bleeding from gastric or duodenal ulcers in the elderly as nonaspirin, non-steroidal anti-inflammatory drugs. The intake of analgesics in 230 patients with bleeding ulcers aged 60 and over and in hospital and community controls matched for age and sex was examined. Those who had taken aspirin were between two and three times more likely to be admitted to hospital with bleeding ulcers. This increased risk was not accounted for by aspirin takes for indigestion or by concurrent use of non-aspirin, non-steroidal anti-inflammatory drugs. A similar effect was not seen for paracetamol.