Prospective surveillance of acute serious liver disease unrelated to infectious, obstructive, or metabolic diseases:: epidemiological and clinical features, and exposure to drugs
Prospective surveillance of acute serious liver disease unrelated to infectious, obstructive, or metabolic diseases:: epidemiological and clinical features, and exposure to drugs
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DOI：
10.1016/s0168-8278(02)00231-3
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发表时间：
2002-11-01
影响因子：
25.7
通讯作者：
Laporte, JR
中科院分区：
文献类型：
--
作者：
Ibáñez, L;Pérez, E;Laporte, JR
背景/目的：与感染性、梗阻性或代谢性疾病无关的急性严重肝病并不常见。许多毒品都被牵连了进来。有关其流行病学的数据很少。我们对西班牙加泰罗尼亚地区的急性重症肝病进行了一项基于人群的前瞻性研究。结果：急性重型肝病的发病率为7.4/10(6)人/年(95%可信区间：6.0~8.8)，且随年龄增长而增加。肝细胞性急性重症肝病的发病率(3.84/10万/年)高于淤胆型和混合型。病死率为11.9%，死亡率为0.8/百万人年。肝细胞型和胆汁淤积型患者的死亡风险相似。非甾体抗炎药、镇痛药和抗菌药物是使用频率最高的药物。结论：与感染性、梗阻性或代谢性疾病无关的急性重症肝病罕见。其发病率随年龄增长而增加。胆汁淤积型急性重症肝病的预后与肝细胞型无显著差异。非类固醇抗炎药、止痛药和抗菌药是最常见的可能导致急性肝病的药物。(C)2002年欧洲肝脏研究协会。爱思唯尔科学公司出版。版权所有。
Background/Aims: Acute serious liver disease which is unrelated to infectious, obstructive, or metabolic disease is uncommon. Many drugs have been implicated. Data on its epidemiology are scarce. We performed a population-based prospective study of acute serious liver disease in Catalonia (Spain).Methods: A collaborating hospital network was set up. All patients with acute serious liver disease and negative viral hepatitis serological markers, without an obvious cause of liver disease, were included.Results: The incidence of acute serious liver disease was 7.4 per 10(6) inhabitants per year (95% CI; 6.0-8.8), which increased with age. The incidence of hepatocellular acute serious liver disease (3.84 per 10(6) per year) was greater than that of cholestatic and mixed patterns. The case-fatality ratio was 11.9% and mortality 0.8 per million person-years. The risk of death was similar among patients with hepatocellular and cholestatic patterns. Non-steroidal antiinflammatory drugs, analgesics, and antibacterials were the most frequently used drugs.Conclusions: Acute serious liver disease which is unrelated to infectious, obstructive, or metabolic disease is rare. Its incidence increases with age. The prognosis of cholestatic acute serious liver disease does not significantly differ from that of the hepatocellular pattern. Non-steroidal antiinflammatory drugs, analgesics, and antibacterials were the most common drugs likely to be responsible for acute liver disease. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.