POSTURAL HYPOTENSION AND LOW R-R INTERVAL VARIABILITY IN PARKINSONISM, SPINO-CEREBELLAR DEGENERATION, AND SHY-DRAGER SYNDROME
POSTURAL HYPOTENSION AND LOW R-R INTERVAL VARIABILITY IN PARKINSONISM, SPINO-CEREBELLAR DEGENERATION, AND SHY-DRAGER SYNDROME
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DOI：
10.1212/wnl.33.4.463
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发表时间：
1983-01-01
期刊：
影响因子：
9.9
通讯作者：
TOYOKURA, Y
中科院分区：
文献类型：
--
作者：
KUROIWA, Y;SHIMADA, Y;TOYOKURA, Y
研究了帕金森病、脊髓小脑变性和 Shy-Drager 综合征患者的收缩压、平均 R-R 间期和 R-R 间期方差。体位性低血压与无汗症相关（P < 0.05），表明交感血管舒缩功能障碍。仰卧时 R-R 间隔方差的减少与膀胱-肠功能障碍相关（P < 0.05），表明副交感神经损伤。姿势改变后 R-R 间期方差的减少与便秘 (P < 0.005)、姿势性低血压 (P < 0.05) 和无汗 (P < 0.05) 相关，表明副交感神经和交感神经都参与其中。 R-R 间期的动态研究提供了有关神经系统疾病自主神经功能的客观信息。
Systolic blood pressure, mean R-R interval and R-R interval variance were studied in patients with Parkinson''s disease, spinocerebellar degeneration and Shy-Drager syndrome. Postural hypotension correlated with anhidrosis (P < 0.05), indicating sympathetic vasomotor dysfunction. Reduction of R-R interval variance while resting supine correlated with bladder-bowel dysfunction (P < 0.05), indicating parasympathetic impairment. Reduction of R-R interval variance after postural changes correlated with constipation (P < 0.005), postural hypotension (P < 0.05) and anhidrosis (P < 0.05), indicating both parasympathetic and sympathetic involvement. Dynamic study of the R-R interval provides objective information about autonomic function in neurologic disease.