Organotropism: new insights into molecular mechanisms of breast cancer metastasis.
Organotropism: new insights into molecular mechanisms of breast cancer metastasis.
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DOI：
10.1038/s41698-018-0047-0
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发表时间：
2018
影响因子：
7.9
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Chen W;Hoffmann AD;Liu H;Liu X
转移占乳腺癌死亡率的90%。尽管在过去的十年中在癌症医学方面取得了重大进展，但我们对转移的理解仍然有限，因此预防和靶向转移尚不可能。乳腺癌细胞优先转移至特定器官，称为“向器官转移”，其受乳腺癌亚型、宿主器官微环境和癌细胞-器官相互作用的调节。癌细胞和宿主器官之间的串扰促进了转移前小生境的形成，并且在癌细胞到达宿主器官之前由癌细胞释放的因子增强。此外，宿主微环境和特定器官结构影响转移性小生境的形成以及癌细胞与局部驻留细胞之间的相互作用，从而调节癌细胞的存活和转移性病变的形成。了解向器官转移的分子机制对于基于生物标志物的预测和预后、创新治疗策略的开发以及最终改善患者预后至关重要。在这篇综述中，我们总结了乳腺癌向器官转移的分子机制，重点是肿瘤细胞的分子改变，干性特征，并与宿主环境的串扰。此外，本文还就乳腺癌向器官转移中的遗传和表观遗传学改变、外泌体、microRNA、循环肿瘤细胞和免疫反应等方面的研究进展进行了综述。
Metastasis accounts for 90% of breast cancer mortality. Despite the significant progress made over the past decade in cancer medicine our understanding of metastasis remains limited, therefore preventing and targeting metastasis is not yet possible. Breast cancer cells preferentially metastasize to specific organs, known as “organotropic metastasis”, which is regulated by subtypes of breast cancer, host organ microenvironment, and cancer cells-organ interactions. The cross-talk between cancer cells and host organs facilitates the formation of the premetastatic niche and is augmented by factors released from cancer cells prior to the cancer cells’ arrival at the host organ. Moreover, host microenvironment and specific organ structure influence metastatic niche formation and interactions between cancer cells and local resident cells, regulating the survival of cancer cells and formation of metastatic lesions. Understanding the molecular mechanisms of organotropic metastasis is essential for biomarker-based prediction and prognosis, development of innovative therapeutic strategy, and eventual improvement of patient outcomes. In this review, we summarize the molecular mechanisms of breast cancer organotropic metastasis by focusing on tumor cell molecular alterations, stemness features, and cross-talk with the host environment. In addition, we also update some new progresses on our understanding about genetic and epigenetic alterations, exosomes, microRNAs, circulating tumor cells and immune response in breast cancer organotropic metastasis.
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影响因子：
4
作者：
Bleckmann A;Conradi LC;Menck K;Schmick NA;Schubert A;Rietkötter E;Arackal J;Middel P;Schambony A;Liersch T;Homayounfar K;Beißbarth T;Klemm F;Binder C;Pukrop T
通讯作者：
Pukrop T
影响因子：
10.5
作者：
Alečković M;Wei Y;LeRoy G;Sidoli S;Liu DD;Garcia BA;Kang Y
通讯作者：
Kang Y
影响因子：
21.3
作者：
Celià-Terrassa T;Liu DD;Choudhury A;Hang X;Wei Y;Zamalloa J;Alfaro-Aco R;Chakrabarti R;Jiang YZ;Koh BI;Smith HA;DeCoste C;Li JJ;Shao ZM;Kang Y
通讯作者：
Kang Y
DOI：
10.1186/bcr2831
发表时间：
2011-03-14
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Blanco MA;Kang Y
通讯作者：
Kang Y
影响因子：
3.4
作者：
Bachmann, C.;Schmidt, S.;Grischke, E.
通讯作者：
Grischke, E.