A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer
A prospective study of stress among women undergoing in vitro fertilization or gamete intrafallopian transfer
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DOI：
10.1016/s0015-0282(01)02008-8
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发表时间：
2001-10-01
影响因子：
6.7
通讯作者：
Sieber, W
中科院分区：
文献类型：
--
作者：
Klonoff-Cohen, H;Chu, E;Sieber, W
目的：评估体外受精（IVF）或配子输卵管内移植（GIFT）过程中的基线或程序压力是否影响妊娠或活产分娩率。设计：前瞻性研究。设置：1993年至1998年期间南加州的7家诊所。患者：151名妇女完成了两份问卷。干预：无。主要结果测量：抽吸和受精的卵母细胞的数量，胚胎移植的数量，妊娠的实现，活产分娩，和婴儿outcomes. Results（s）：积极影响消极影响得分在基线的卵母细胞和胚胎移植的数量产生负面影响。更高的妊娠期望值与更多的卵母细胞、受精和胚胎移植有关。在基线时，与得分最低的女性相比，得分最高的女性的无活产风险降低了93%。此外。不孕反应量表的得分与活产分娩、婴儿出生体重和多胎分娩的阴性结局有关。在手术期间，PANAS和双极情绪状态特征结果与受精卵和移植胚胎的数量有关;压力不影响妊娠或分娩。获取和受精的卵母细胞数量），以及妊娠、活产分娩、出生体重和多胎妊娠，而（程序性）应激仅影响生物学终点。（Fertil Steril（R）2001;76：675-87. (C)2001年由美国生殖医学学会出版。
Objective: To evaluate whether baseline or procedural stress during in vitro fertilization (IVF) or gamete intrafallopian transfer (GIFT) affects pregnancy or live birth delivery rates.Design: Prospective study.Setting: Seven clinics in Southern California between 1993 and 1998.Patient(s): One hundred and fifty-one women completed two questionnaires.Intervention(s): None.Main Outcome Measure(s): The number of oocytes aspirated and fertilized, the number of embryos transferred, the achievement of a pregnancy, live birth delivery, and infant outcomes.Result(s): Positive-affect negative-affect score at baseline negatively influenced the number of oocytes retrieved and embryos transferred. A higher expectation of pregnancy was associated with greater numbers of oocytes, fertilized and embryos transferred. At baseline, the risk of no live birth was 93% lower for women who had the highest positive-affect score compared to those with the lowest score. Furthermore. the score on the Infertility Reaction Scale was related to negative outcomes in Live birth delivery, infant birth weight, and multiple births. During the time of the procedure, the PANAS and Bipolar Profile of Moods States results were related to the number of oocytes fertilized and embryos transferred; stress did not affect pregnancy or delivery.Conclusion(s): Baseline (acute and chronic) stress affected biologic end points (i.e., number of oocytes retrieved and fertilized), as well as pregnancy, live birth delivery, birth weight, and multiple gestations, whereas (procedural) stress only influenced biologic end points. (Fertil Steril(R) 2001;76:675-87. (C) 2001 by American Society for Reproductive Medicine.).