Glycine absorption in operative hysteroscopy: the impact of anesthesia
Glycine absorption in operative hysteroscopy: the impact of anesthesia
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DOI：
10.1016/j.ajog.2008.12.024
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发表时间：
2009-03-01
影响因子：
9.8
通讯作者：
Laberge, Philippe
中科院分区：
文献类型：
--
作者：
Bergeron, Marie-Eve;Beaudet, Christine;Laberge, Philippe
目的：本研究旨在评价麻醉对宫腔镜术中甘氨酸吸收的影响。研究设计：两年多的回顾性队列研究。比较全身麻醉、局麻加静脉镇静和脊麻对甘氨酸的吸收。多因素Logistic回归分析。结果：共回顾了282例手术中的宫腔镜检。全身麻醉吸收中位数为145毫升(10~90百分位数：0~963毫升)，局部麻醉组为35毫升(10~90百分位数：0~389毫升)，脊麻为100毫升(10~90百分位数：0~500毫升)(P=0.002)。与全身麻醉组相比，局麻组吸收率较低，500-1000mL(4.2%比13.4%)和1000-1500毫升(3.6%比9.8；P=0.002)。腹腔镜输卵管结扎术与甘氨酸吸收显著相关(优势比为3.63，95%可信区间为1.12~11.84)。结论：与全身麻醉相比，镇静状态下局部麻醉甘氨酸吸收显著减少，甘氨酸吸收速率降低。
OBJECTIVE: This study aimed to evaluate the impact of anesthesia on the absorption of glycine in operative hysteroscopy.STUDY DESIGN: A retrospective cohort study was performed over 2 years. The absorption of glycine was compared among general anesthesia, local anesthesia with intravenous sedation, and spinal anesthesia. Multiple logistic regression analyses were performed.RESULTS: In all, 282 operative hysteroscopies were reviewed. The median absorption was 145 mL (10th-90th centile: 0-963 mL) for general anesthesia, 35 mL (10th-90th centile: 0-389 mL) for local anesthesia, and 100 mL (10th-90th centile: 0-500 mL) for spinal anesthesia (P = .002). In comparison with general anesthesia, local anesthesia was associated with lower rate of absorption of 500-1000 mL (4.2% vs 13.4%) and of 1000-1500 mL (3.6% vs 9.8; P = .002). Laparoscopic tubal ligation performed during the procedure was also associated with higher glycine absorption (odds ratio, 3.63; 95% confidence interval, 1.12-11.84).CONCLUSIONS: Local anesthesia with sedation is associated with significantly decreased glycine absorption and lower rate of absorption > 500 mL when compared with general anesthesia.