Synthetic studies on N-methylwelwitindolinone C isothiocyanate (welwistatin) and related substructures
Synthetic studies on N-methylwelwitindolinone C isothiocyanate (welwistatin) and related substructures
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DOI：
10.2174/1570179043485439
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发表时间：
2004-01-01
影响因子：
1.8
通讯作者：
Menéndez, JC
中科院分区：
文献类型：
--
作者：
Avendaño, C;Menéndez, JC
N-Methylwelwitindolinone C isothiocyanate (welwistatin), isolated from the blue-green alga Hapalosiphon welwitschii, is a potent MDR inhibitor. This review deals with synthetic efforts aimed at welwistatin itself or its fragments, together with work concerning the bicyclo[4.3.1]decane and cyclohepta[cd]indole systems, which are related to the CD and ABC fragments of the natural product.
