Striatal BOLD and Midfrontal Theta Power Express Motivation for Action.

Striatal BOLD and Midfrontal Theta Power Express Motivation for Action.
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纹状体BOLD和中额叶Theta功率表达行动动机。

DOI:
10.1093/cercor/bhab391
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发表时间:
2022-07-12
期刊:
Cerebral cortex (New York, N.Y. : 1991)
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其他
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行动选择会因预期结果的效价而产生偏差。为了评估这些动机偏差的表达和控制机制,我们利用脑电图的时间分辨率和功能磁共振成像的皮质下通道,在动机 Go/NoGo 学习任务 (N = 36) 期间测量了同步 EEG-fMRI。 VmPFC BOLD 编码提示价,重要的是预测逐次试验价驱动的响应速度差异和提示开始周围的脑电图 theta 功率。相比之下,纹状体 BOLD 编码主动 Go 响应的选择,并与响应时间周围的 θ 功率相关。在试验中,theta 功率以证据积累信号的形式增强,以表明做出“Go”反应的价值,捕获对奖励线索的更快反应。我们的研究结果揭示了中额叶 theta 能量的双重性质,早期成分反映了 vmPFC 对动机偏差的贡献,晚期成分反映了纹状体对行为的转化,这与最近有影响力的纹状体加工“工作价值”理论一致。
Action selection is biased by the valence of anticipated outcomes. To assess mechanisms by which these motivational biases are expressed and controlled, we measured simultaneous EEG-fMRI during a motivational Go/NoGo learning task (N = 36), leveraging the temporal resolution of EEG and subcortical access of fMRI. VmPFC BOLD encoded cue valence, importantly predicting trial-by-trial valence-driven response speed differences and EEG theta power around cue onset. In contrast, striatal BOLD encoded selection of active Go responses and correlated with theta power around response time. Within trials, theta power ramped in the fashion of an evidence accumulation signal for the value of making a “Go” response, capturing the faster responding to reward cues. Our findings reveal a dual nature of midfrontal theta power, with early components reflecting the vmPFC contribution to motivational biases, and late components reflecting their striatal translation into behavior, in line with influential recent “value of work” theories of striatal processing.
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