Association between different levels of dysglycemia and metabolic syndrome in pregnancy
Association between different levels of dysglycemia and metabolic syndrome in pregnancy
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DOI：
10.1186/1758-5996-1-3
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发表时间：
2009-01-01
影响因子：
4.8
通讯作者：
Rudge, Marilza V. C.
中科院分区：
文献类型：
--
作者：
Negrato, Carlos A.;Jovanovic, Lois;Rudge, Marilza V. C.
背景：在这项研究中，我们试图评估一组具有广泛糖耐量的孕妇中代谢综合征 (MS) 的患病率、妊娠期间 MS 的孕前危险因素，以及 MS 对母亲和新生儿结局的影响。方法：通过两种诊断方法对 136 名妊娠期糖尿病 (GDM) 筛查呈阳性的女性进行分类：血糖曲线和 100 g OGTT 为血糖正常、轻度妊娠期糖尿病。高血糖、GDM 和明显的 GDM。在筛选期间测量2428(th)之间的MS标志物。结果：MS的患病率为：0%； 20.0%；血糖正常组、轻度高血糖组、GDM 组和明显 GDM 组分别为 23.5% 和 36.4%。既往有或没有使用胰岛素的 GDM 病史、BMI >= 25、高血压、一级亲属有糖尿病家族史、非白种人种、早产史和羊水过多是妊娠期 MS 的具有统计学意义的孕前预测因素，这反过来又增加了母亲和新生儿的不良后果。结论：MS 的患病率随着糖耐量的恶化而增加；即使在 OGTT 正常的情况下，血糖谱受损也可以识别未归类为 GDM 的患者中存在重要代谢异常的妊娠。
Background: In this study, we sought to evaluate the prevalence of metabolic syndrome (MS) in a cohort of pregnant women with a wide range of glucose tolerance, prepregnancy risk factors for MS during pregnancy, and the effects of MS in the outcomes in the mother and in the newborn.Methods: One hundred and thirty six women with positive screening for gestational diabetes mellitus (GDM) were classified by two diagnostic methods: glycemic profile and 100 g OGTT as normoglycemic, mild gestational hyperglycemic, GDM, and overt GDM. Markers of MS were measured between 2428(th) during the screening.Results: The prevalence of MS was: 0%; 20.0%; 23.5% and 36.4% in normoglycemic, mild hyperglycemic, GDM, and overt GDM groups, respectively. Previous history of GDM with or without insulin use, BMI >= 25, hypertension, family history of diabetes in first degree relatives, non-Caucasian ethnicity, history of prematurity and polihydramnios were statistically significant prepregnancy predictors for MS in the index pregnancy, that by its turn increased the adverse outcomes in the mother and in the newborn.Conclusion: The prevalence of MS increases with the worsening of glucose tolerance; impaired glycemic profile identifies pregnancies with important metabolic abnormalities even in the presence of a normal OGTT, in patients that are not classified as having GDM.