Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in adenoid cystic carcinoma of the head and neck: Correlation with clinical outcome
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in adenoid cystic carcinoma of the head and neck: Correlation with clinical outcome
复制标题
DOI：
10.1016/j.oraloncology.2006.08.005
复制
发表时间：
2007-08-01
期刊：
影响因子：
4.8
通讯作者：
Furuya, Nobuhiko
中科院分区：
文献类型：
--
作者：
Chikamatsu, Kazuaki;Shino, Masato;Furuya, Nobuhiko
本研究的目的是评估胸苷酸合酶(TS)、二氢嘧啶脱氢酶(DPD)和P53作为预测腺样囊性癌(ACC)临床预后的可能性。采用免疫组织化学方法检测27例ACC中TS、DPD和P53的表达，并探讨其与临床病理因素的关系。Dpd高表达的远处转移率显著高于Dpd高表达的患者(p=0.001)，而TS和P53的表达与临床病理因素均无明显相关性。有趣的是，14名早期患者中有6名有远处转移，他们所有的肿瘤都显示出高DPD表达。Kaplan-Meier分析显示，可靠的组织学类型和远处转移与预后不良相关。在肿瘤完全切除的早期患者中，TS或DPD高表达患者的预后较低表达患者差，但差异无统计学意义(TS，p=0.178；DPD，p=0.251)。我们的结果表明，评估DPD在ACC中的表达可能是一种有用的工具。在确定治疗方式以及评估临床结果方面。(C)2006爱思唯尔有限公司。保留所有权利。
The purpose of this study was to estimate the possibility of using thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and p53 as predictive values of clinical outcome in adenoid cystic carcinoma (ACC). The expressions of TS, DPD, and p53 were examined with immunohistochemistry in 27 ACC patients, and the association with clinicopathological factors was determined. Cases with high DPD expression had significantly higher distant metastasis rates compared to those with tow DPD expression (p = 0.001), whereas neither TS nor p53 expression showed any significant correlation to clinicopathological factors. Interestingly, six of 14 early-stage patients had distant metastases and all of their tumors showed high DPD expression. Kaplan-Meier analysis revealed that a solid histological pattern and distant metastasis correlated with a poor prognosis. In early-stage patients, whose tumor was completely resected, those with high TS or DPD expression had a worse prognosis compared to those with low expression, but the difference did not reach statistical significance (TS, p = 0.178; DPD, p = 0.251). Our results suggest that assessment of DPD expression in ACC may be a useful tool. in determining the mode of treatment as well as evaluating clinical outcome. (C) 2006 Elsevier Ltd. All rights reserved.