Cystatin C predicts acute kidney injury and mortality in cirrhotics: A prospective cohort study
Cystatin C predicts acute kidney injury and mortality in cirrhotics: A prospective cohort study
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DOI：
10.1111/liv.13600
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发表时间：
2018-04-01
影响因子：
6.7
通讯作者：
Sarin, Shiv K.
中科院分区：
文献类型：
--
作者：
Maiwall, Rakhi;Kumar, Awinash;Sarin, Shiv K.
背景与目的急性肾损伤是肝硬变常见的不祥并发症。AKI的一次发作损害了功能性肾单位，损害了肾功能储备。我们的目标是研究AKI的发生率，随后发生的概率，AKI本身是否易患未来的AKI，以及血清胱抑素C(SCyC)作为生物标记物在前瞻性的肝硬变队列中的可靠性。AKI和死亡率的预测模型被开发和验证(Gr。A，衍生队列[n=273]，Gr.B，验证队列[n=258])。结果233名患者发生了365次AKI；平均每个患者发生1.56次AKI。在乔治亚州A组和B组分别有97例(35.5%)和78例(30%)患者有AKI发作史，并有进一步发作的倾向(Gr。A，HR 3.9，95%CI 2.7~5.6，Gr.B，HR 3.6，95%可信区间2.5~5.4)。因此，Aki是新AKI发展的独立预测因子(P
Background & AimsAcute kidney injury is a frequent and ominous complication in cirrhosis. An episode of AKI damages the functional nephron mass, compromising the renal functional reserve. We aimed to study the incidence of AKI, probability of subsequent episodes, whether AKI itself predisposes to future AKI and the reliability of serum cystatin C(sCyC) as a biomarker in a prospective cohort of cirrhotics.Patients and MethodsFive hundred and thirty-one cirrhotics without ongoing AKI were followed for development/resolution of AKI. Predictive models for AKI and mortality were developed and validated (Gr. A, Derivative cohort [n=273], Gr. B, Validation Cohort [n=258]).Results365 episodes of AKI occurred in 233 patients; yielding a mean of 1.56 episodes of AKI per patient. In Gr. A and B, 97 (35.5%) and 78 (30%) patients had prior AKI episodes and were predisposed to further attacks (Gr. A, HR 3.9, 95% CI 2.7-5.6, Gr. B, HR 3.6, 95% CI 2.5-5.4). AKI was thus an independent predictor of the development of new AKI(P