Thyroid Patient Salivary Radioiodine Transit and Dysfunction Assessment Using Chewing Gums
Thyroid Patient Salivary Radioiodine Transit and Dysfunction Assessment Using Chewing Gums
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DOI：
10.1089/cbr.2016.2076
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发表时间：
2016-11
影响因子：
3.4
通讯作者：
OkkalidesDemetrios
中科院分区：
文献类型：
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作者：
OkkalidesDemetrios
放射性唾液腺功能障碍是碘-131治疗甲状腺最常见的副作用。在这里，一种新的唾液采样方法与普通的口香糖给予患者在适当的时间间隔后治疗（TIPT）被用来将这种效果与口香糖唾液活性（CGSA）的内容。在2014年和2015年期间，对19例分化型甲状腺癌（DTC）和16例放射性同位素单位（RIU）甲状腺功能亢进症患者口服规定的I-131活性（放射性给药[RA]）后采集唾液样本。该唾液采集过程的误差为1.2%-2.05%，因此认为该方法是令人满意的。对于每例患者，绘制CGSA与TIPT的曲线，R（t）。在此基础上，拟合了两个函数：前几个上升数据点上的线性函数和R（t）峰值上的伽马变量。由此计算了与放射性口渡有关的几个参数，并计算了总放射性活度。
Abstract Radiation-induced salivary gland dysfunction is the most frequent side-effect of I-131 thyroid therapy. Here, a novel saliva sampling method with ordinary chewing gums administered to the patients at appropriate time intervals post-treatment (TIPT) was used to relate this effect to chewing gum saliva activity (CGSA) content. Saliva samples were acquired after the oral administration of prescribed I-131 activity (radioactivity administered [RA]) to 19 differentiated thyroid cancer (DTC) and 16 hyperthyroidism patients of the radioisotope unit (RIU) during 2014 and 2015. The error of this saliva collecting process was found to be 1.2%–2.05%, and so, the method was considered satisfactory. For each patient, the CGSA was plotted against the TIPT producing a curve, R(t). On this, two functions were fitted: a linear on the first few rising data points and a gamma variate over the peak of the R(t). From these, several parameters related to the radioactivity oral transit were calculated and the total rad...