A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapy
A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implications for antiviral therapy
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作者：
Yuen, MF;Yuan, HJ;Lai, CL
背景和目的：来自大规模人群研究的自发性B e抗原（HBeAg）血清转换和慢性B型肝炎（CH B）病毒感染急性加重的临床数据正在锁定。在本研究中，我们研究了3063中国慢性乙型肝炎（CHB）患者HBeAg血清转换和急性加重的临床特征和意义。方法：临床评估，肝生化，B型肝炎病毒（HBV）血清学和HBV DNA，HBeAg血清转换的时间，和急性加重进行了监测。累积HBeAg血清转换率随着就诊时丙氨酸氨基转移酶（ALT）水平的升高而显着升高（p
Background and aim: Clinical data on spontaneous hepatitis B e antigen (HBeAg) seroconversion and acute exacerbation of chronic hepatitis B (CHB) virus infection from large population studies are locking. In the present study we examined the clinical features and significance of HBeAg seroconversion and acute exacerbation in 3063 Chinese CHB patients.Methods: Clinical assessment, liver biochemistry, hepatitis B virus (HBV) serology and HBV DNA, time of HBeAg seroconversion, and acute exacerbation were monitored.Results: Median age at HBeAg seroconversion was 34.5 years. The cumulative HBeAg seroconversion rate significantly increased with alanine aminotransferase (ALT) levels on presentation (p