Abnormal hematopoiesis and hematopoietic stem cell niche
Abnormal hematopoiesis and hematopoietic stem cell niche
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造血异常与造血干细胞生态位
DOI：
10.11406/rinketsu.58.1844
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
小林 央
中科院分区：
文献类型：
--
作者：
田久保 圭誉;森川 隆之;小林 央
在稳态条件下，造血干细胞(HSCs)在细胞周期中保持静止状态。当受到感染或炎症时，骨髓间充质干细胞开始增殖，并通过多向分化和自我更新产生分化的造血细胞；这种效应部分是由于其周围微环境或生态位的改变。此外，最近的研究表明，骨髓巢在包括白血病发生在内的异常造血中起着至关重要的作用。在这篇综述中，我们讨论了我们对HSC/NICE功能的理解的最新进展，以及在动态平衡、应激性造血或疾病条件下使用的调节机制。
During steady-state conditions, hematopoietic stem cells (HSCs) maintain a quiescent status in the cell cycle. Upon infection or inflammation, bone marrow HSCs begin proliferating and generating differentiated hematopoietic cells via multi-lineage differentiation and self-renewal; this effect is partially due to the alteration of their surrounding microenvironment or niche. In addition, recent studies have revealed that the bone marrow niche critically contributes to abnormal hematopoiesis, including leukemogenesis. In this review, we discuss the recent advances in our understanding of HSC/niche functions and the regulatory machineries employed during homeostasis, stress hematopoiesis, or disease conditions.