Speech and language functions that require a functioning Broca's area
Speech and language functions that require a functioning Broca's area
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DOI：
10.1016/j.bandl.2008.01.012
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发表时间：
2008-04-01
影响因子：
2.5
通讯作者：
Hillis, Argye E.
中科院分区：
文献类型：
--
作者：
Davis, Cameron;Kleinman, Jonathan T.;Hillis, Argye E.
许多先前的研究表明，布罗卡区在理解和产生句法复杂的句子和其他语言功能中起着重要作用。如果布罗卡区对这些功能至关重要，那么布罗卡区的梗死或该区域内的暂时性灌注不足应导致这些功能的损害，至少在神经组织功能障碍时是如此。一名超急性中风患者提供了识别依赖于特定个体的布罗卡区的语言功能的机会，该患者表现出布罗卡区选择性灌注不足，伴有轻微梗死，语法句子的产生、语义可逆（但不是不可逆）句子的理解、拼写和言语清晰度的运动规划严重受损。当血流恢复到布罗卡区时，如重复灌注加权成像所示，他显示这些语言功能立即恢复。当布罗卡区功能障碍（由于低血流量）时，语言功能受损，当布罗卡区再次发挥功能时，语言功能恢复，这为布罗卡区在这些语言功能中的关键作用提供了证据，至少在这个人身上。(c)2008年由Elsevier Inc.出版
A number of previous studies have indicated that Broca's area has an important role in understanding and producing syntactically complex sentences and other language functions. If Broca's area is critical for these functions, then either infarction of Broca's area or temporary hypoperfusion within this region should cause impairment of these functions, at least while the neural tissue is dysfunctional. The opportunity to identify the language functions that depend on Broca's area in a particular individual was provided by a patient with hyperacute stroke who showed selective hypoperfusion, with minimal infarct, in Broca's area, and acutely impaired production of grammatical sentences, comprehension of semantically reversible (but not non-reversible) sentences, spelling, and motor planning of speech articulation. When blood flow was restored to Broca's area, as demonstrated by repeat perfusion weighted imaging, he showed immediate recovery of these language functions. The identification of language functions that were impaired when Broca's area was dysfunctional (due to low blood flow) and recovered when Broca's area was functional again, provides evidence for the critical role of Broca's area in these language functions, at least in this individual. (c) 2008 Published by Elsevier Inc.