Fibronectin and viral pathogenesis.
Fibronectin and viral pathogenesis.
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DOI：
10.1093/clinids/9.supplement_4.s404
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发表时间：
1987-07
期刊：
影响因子：
--
通讯作者：
J. Keski‐oja;A. Hautanen;I. Julkunen
中科院分区：
文献类型：
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作者：
J. Keski‐oja;A. Hautanen;I. Julkunen
纤连蛋白是由两个相似但不相同的亚基组成的二聚体高分子量糖蛋白。已经观察到血浆和细胞来源的纤连蛋白之间的差异，并且分子和测序研究已经揭示了结构域结构。纤连蛋白的特征包括其各种分子和生物学相互作用，这些相互作用可以分配给分子的不同结构域。纤连蛋白最初是作为病毒转化细胞表面缺失的蛋白质被发现的。功能性癌基因在细胞外基质损失中的重要性后来在许多使用对转化温度敏感的病毒突变体的研究中确立。细胞外基质的丢失似乎是细胞中多种事件的结果，但不是体内恶性生长的先决条件。似乎有多种转化的表型，细胞外纤连蛋白的丢失可能部分是由于细胞的蛋白水解活性和功能性癌基因引起的其他改变。纤连蛋白的组织和可溶形式的广泛分布为与其他分子的相互作用提供了多种场合。在许多研究中已经观察到纤连蛋白与病毒和纯化的病毒蛋白的结合。纤连蛋白分子中神经氨酸酶敏感的病毒结合位点已被初步确定。纤连蛋白还能够结合各种补体成分，可能使病毒感染期间在循环中观察到的病毒抗原-抗体-补体复合物的清除更快。纤连蛋白的病毒结合能力可能在改变体内病毒感染中发挥作用。
Fibronectin is a dimeric high-molecular-weight glycoprotein composed of two similar but not identical subunits. Differences have been observed between plasma and cell-derived fibronectins, and molecular and sequencing studies have revealed a domain structure. The characteristic features of fibronectin include its various molecular and biologic interactions, which can be assigned to the different domains of the molecule. Fibronectin was originally discovered as a protein missing from the surfaces of virus-transformed cells. The importance of functional oncogenes in the loss of extracellular matrices was later established in a number of studies using virus mutants that are temperature-sensitive for transformation. The loss of the extracellular matrix appears to be a result of multiple events in cells but is not a prerequisite for malignant growth in vivo. There appear to be multiple transformed phenotypes, and the loss of extracellular fibronectin may be due in part to proteolytic activity by the cells and other alterations caused by functioning oncogenes. The wide distribution of tissue and soluble forms of fibronectin offers multiple occasions for interactions with other molecules. Binding of fibronectin to viruses and purified viral proteins has been observed in a number of studies. Neuraminidase-sensitive virus-binding sites in the fibronectin molecule have tentatively been identified. Fibronectin also is capable of binding to various complement components, possibly making clearance of viral antigen-antibody-complement complexes, which are observed in the circulation during viral infection, more rapid. The virus-binding ability of fibronectin may play a role in modifying viral infections in the body.