Benidipine-loaded nanoflower-likemagnesium silicate improves bone regeneration
Benidipine-loaded nanoflower-likemagnesium silicate improves bone regeneration
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DOI：
10.1007/s42242-023-00240-8
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发表时间：
2023-06-16
影响因子：
7.9
通讯作者：
Wang, Huiming
中科院分区：
文献类型：
--
作者：
Lu, Jingyi;Sun, Miao;Wang, Huiming
由于骨修复材料对成骨细胞的长期有效作用的不确定性，骨组织的再生和重建一直是临床医生面临的挑战。在这里，我们提出了一种新的策略，结合贝尼地平，抗高血压药物和纳米粒子，以协同促进骨缺损的愈合。制备了疏松多孔的贝尼地平硅酸镁纳米粒，并对其生物安全性进行了验证。纳米颗粒被前成骨细胞有效吸收并均匀分布在细胞核周围。内化进入细胞后，纳米系统被溶酶体降解，促进成骨分化的作用通过贝尼地平、硅和镁离子的持续释放来体现。我们的结果清楚地评价了纳米花状硅酸镁递送贝尼地平倾向于更适合于前成骨细胞的骨再生，表明其可能是临床应用中指导骨修复的潜在方法。
Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on osteoblasts. Here, we propose a novel strategy combining benidipine, an antihypertensive drug and nanoparticles to synergistically promote the healing of bone defects. Loose and porous benidipineloaded magnesium silicate nanoparticles were prepared and validated for their biosafety. The nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the nucleus. After internalization into cells, the nanosystem is degraded by lysosomes, and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine, silicon and magnesium ions. Our results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts, indicating that it might be a potential approach in guiding bone repair in clinical applications.