State-of-the-art in microreaction technology:: concepts, manufacturing and applications
State-of-the-art in microreaction technology:: concepts, manufacturing and applications
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DOI：
10.1016/s0013-4686(99)00071-7
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发表时间：
1999-01-01
影响因子：
6.6
通讯作者：
Ehrfeld, W
中科院分区：
文献类型：
--
作者：
Löwe, H;Ehrfeld, W
微反应器作为化学技术中的一个新概念，使得在化学、分子生物学和药物化学中引入新的反应流程成为可能。如今，微反应器被实现为小型化的连续流动系统或反应容器，其典型的通道或腔室宽度在10 - 500微米范围内。特征尺寸的减小导致反应腔体积变小，从而能够应用高温或反应物浓度梯度，并且显著增强过程控制和热管理。因此，微反应系统的独特优势在于能够在特殊的工艺条件或等温条件下进行化学反应。此外，微反应器能够在现场或按需生产有毒或易爆化学品，且具有本质安全性。最近，微反应器在工艺开发和工业研究中变得越来越重要。一个成功应用的例子是通过均相催化的液/液相反应合成一种维生素前体。其他一些类型的化学反应，例如气相反应（环氧乙烷的生成）或两相体系（气/液），正在研究中。1999年爱思唯尔科学有限公司版权所有。
Microreactors as a novel concept in chemical technology enable the introduction of new reaction procedures in chemistry, molecular biology and pharmaceutical chemistry. Today, microreactors are realized as miniaturized continuous flow systems or reaction vessels with typical channel or chamber widths in the range of 10-500 mu m. The reduction of characteristic dimensions resulting in a small volume of the reaction tone allows an application of high temperature or reactant concentration gradients, as well as a significantly enhanced process control and heat management. Thereby, the unique advantages of microreaction systems are to carry out chemical reactions in unusual process regimes or under isothermal conditions. In addition, microreactors offer the production of toxic or explosive chemicals onsite or ondemand with an inherent safety.Recently, microreactors gain more and more relevance in process development and industrial research. One example for a successful application is the synthesis of a vitamin precursor by a homogeneously catalyzed liquid/liquid-phase reaction. Some other classes of chemical reactions, e.g. gas phase reactions (formation of ethylene oxide) or two phase systems (gas/liquid), are under investigation. (C) 1999 Elsevier Science Ltd. All rights reserved.