Tolerance and suppression of immunity to herpes simplex virus: different presentations of antigens induce different types of suppressor cells.
Tolerance and suppression of immunity to herpes simplex virus: different presentations of antigens induce different types of suppressor cells.
复制标题
对单纯疱疹病毒免疫的耐受和抑制：抗原的不同呈递诱导不同类型的抑制细胞。
DOI：
10.1128/iai.40.2.514-522.1983
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发表时间：
1983
影响因子：
3.1
通讯作者：
Moorhead,JW
中科院分区：
文献类型：
--
作者：
Schrier,RD;Pizer,LI;Moorhead,JW
在这份报告中，我们研究耐受性（低反应性）和抑制迟发型超敏反应（DH）单纯疱疹病毒（HSV）在小鼠中，使用两种不同形式的耐受原：HSV颗粒和HSV感染的脾细胞。在用病毒皮下免疫前7天，用HSV颗粒或脾细胞静脉内注射小鼠诱导了深刻的无反应状态。这种无反应状态至少部分是由抑制性T细胞（Ts）介导的，这一点通过被动转移到幼稚受体中得到了证明。然而，根据耐受原的形式诱导不同类型的Ts。注射HSV颗粒诱导Ts，Ts抑制诱导但不抑制DH的表达。另一方面，注射HSV脾细胞诱导两种类型的Ts：一种抑制DH应答的诱导，另一种抑制DH对HSV的表达。耐受性和Ts都是病毒特异性的（即，对不相关病毒的DH应答没有被抑制），但对HSV 1型和HSV 2型没有类型特异性。由于病毒颗粒和病毒感染的细胞在HSV感染期间都可能存在于血液中，因此这种类型的免疫调节的诱导可能影响急性和潜伏性HSV感染的结果。
In this report, we examine tolerance (hyporesponsiveness) and suppression of delayed hypersensitivity (DH) to herpes simplex virus (HSV) in mice, using two different forms of tolerogen: HSV particles and HSV-infected spleen cells. The intravenous injection of mice with either HSV particles or spleen cells 7 days before subcutaneous immunization with virus induced a profound state of unresponsiveness. This unresponsive state was mediated, at least in part, by suppressor T cells (Ts), which were demonstrated by passive transfer to naive recipients. However, different types of Ts were induced depending on the form of the tolerogen. The injection of HSV particles induced Ts which suppressed the induction but not the expression of DH. On the other hand, the injection of HSV spleen cells induced two types of Ts: one which inhibited the induction of the DH response and one which inhibited the expression of DH to HSV. Both tolerance and Ts are virus specific (i.e., the DH response to an unrelated virus was not inhibited) but not type specific for HSV type 1 and HSV type 2. Since both virus particles and virus-infected cells may be present in the blood during HSV infection, the induction of this type of immune regulation may influence the outcome of both acute and latent HSV infections.