The Impact of Endocrine Disruptors on Female Pubertal Timing
The Impact of Endocrine Disruptors on Female Pubertal Timing
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DOI：
10.1007/978-1-60761-561-3_13
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Parent, Anne-Simone
中科院分区：
文献类型：
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作者：
Bourguignon, Jean-Pierre;Parent, Anne-Simone
Secular changes in pubertal timing and particular forms of sexual precocity after migration to new geographical areas whose levels of environment differ from those in the natal country suggest that endocrine-disrupting compounds (EDCs) may be involved. Studies in humans based on measurement of some EDC in relation to pubertal timing are inconclusive for several possible reasons including predominant genetic determinism and effects of complex EDC mixtures. Based on animal models, some possible neuroendocrine mechanisms are discussed as well as the interrelation between the homeostasis of reproduction and energy balance.
