The role of the left posterior parietal lobule in top-down modulation on space-based attention: A transcranial magnetic stimulation study
The role of the left posterior parietal lobule in top-down modulation on space-based attention: A transcranial magnetic stimulation study
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左后顶叶小叶在空间注意力自上而下调节中的作用：经颅磁刺激研究
DOI：
10.1002/hbm.21383
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发表时间：
2012-10-01
影响因子：
4.8
通讯作者：
Zhou, Ke
中科院分区：
文献类型：
--
作者：
Du, Xiaoming;Chen, Lin;Zhou, Ke
来自神经成像以及损伤和经颅磁刺激(TMS)研究的聚合证据表明，右腹后顶叶皮质(PPC)参与了外源性定向。然而，背侧PPC对注意定向，特别是内源性定向的贡献仍存在争议。在信息性外周线索范式中，外源性和内源性定向可以在单个任务中相对独立地研究，我们对背侧PPC的亚区进行了TMS研究，以探索它们可能参与外源性和内源性过程的不同情况。我们发现，切断左侧后顶内沟(PIPS)减弱了内源性定向的注意效应，但不影响外源性加工。此外，在右侧顶上小叶(SPL)上应用TMS可导致反应时间的总体增加。本研究提供的因果证据表明，左侧PIPs在视觉注意的自愿定向中起关键作用，而右侧SPL参与觉醒和/或警觉的加工。《哼唱大脑地图》33：24772486,2012年。(C)2011年威利期刊公司。
Converging evidence from neuroimaging as well as lesion and transcranial magnetic stimulation (TMS) studies has been obtained for the involvement of right ventral posterior parietal cortex (PPC) in exogenous orienting. However, the contribution of dorsal PPC to attentional orienting, particularly endogenous orienting, is still under debate. In an informative peripheral cueing paradigm, in which the exogenous and endogenous orienting can be studied in relative isolation within a single task, we applied TMS over sub-regions of dorsal PPC to explore their possible distinct involvement in exogenous and endogenous processes. We found that disruption of the left posterior intraparietal sulcus (pIPS) weakened the attentional effects of endogenous orienting, but did not affect exogenous processes. In addition, TMS applied over the right superior parietal lobule (SPL) resulted in an overall increase in reaction times. The present study provides the causal evidence that the left pIPS plays a crucial role in voluntary orienting of visual attention, while right SPL is involved in the processing of arousal and/or vigilance. Hum Brain Mapp 33:24772486, 2012. (c) 2011 Wiley Periodicals, Inc.