Population-based cohort study suggesting a significantly increased risk of developing chronic obstructive pulmonary disease in people with type 2 diabetes mellitus
Population-based cohort study suggesting a significantly increased risk of developing chronic obstructive pulmonary disease in people with type 2 diabetes mellitus
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DOI：
10.1016/j.diabres.2018.01.037
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发表时间：
2018-04-01
影响因子：
5.1
通讯作者：
Li, Chung-Yi
中科院分区：
文献类型：
--
作者：
Hsu, I-Lin;Lu, Chin-Li;Li, Chung-Yi
目的：探讨2型糖尿病（T2 DM）是否增加慢性阻塞性肺疾病（COPD）的风险。方法：本研究采用台湾全民健康保险理赔数据，以人群为基础的队列研究，探讨T2 DM与COPD风险的关系。2002-2003年，共确定了716，623对人群（T2 DM患者及其年龄、性别和日历年匹配的对照组），并对其进行了随访，直至新诊断的COPD发生或2011年底。采用考克斯比例风险模型分析COPD发病率与2型糖尿病的关系。结果：2型糖尿病患者COPD发病率高于对照组（159.6 vs 122.7/10（4）人年）。在控制混杂因素后，T2 DM显著增加了COPD的风险（风险比[HR] = 1.15，95%置信区间= 1.14-1.16）。分层分析表明，女性T2 DM与COPD之间的相关性略高于男性（HR，1.15 vs. 1.11）和年龄≥ 65岁的人群（男性HR为1.17比1.05;女性HR为1.16比1.13）。我们的研究结果表明，T2 DM与发生COPD的风险存在适度相关性，可能揭示了高血糖对肺功能的不良影响。(C)2018 Elsevier B. V.版权所有。
Aims: To investigate whether type 2 diabetes mellitus (T2DM) increases the risk of developing chronic obstructive pulmonary disease (COPD).Methods: This population-based cohort study used Taiwan's National Health insurance claim data to investigate the association of T2DM with the risk of COPD. A total of 716,623 pairs of people (patients with T2DM and their age-, sex-, and calendar year-matched controls) were identified in 2002-2003 and were followed until the occurrence of newly-diagnosed COPD or the end of 2011. Cox proportional hazard models were used to relate COPD incidence to T2DM.Results: People with T2DM experienced a higher incidence rate of COPD than controls (159.6 vs 122.7 per 10(4) person-years). After controlling for confounders, T2DM significantly increased the hazard of COPD (hazard ratio [HR] = 1.15, 95% confidence interval = 1.14-1.16). Stratified analysis indicated that the association between T2DM and COPD was slightly greater in women than in men (HR, 1.15 vs. 1.11) and in people aged = 65 years (HR, 1.17 vs. 1.05 in men; 1.16 vs. 1.13 in women).Conclusions: Our findings demonstrated a modest association of T2DM with the risk of developing COPD, possibly shedding light into the adverse effects of hyperglycemia on pulmonary function. (C) 2018 Elsevier B.V. All rights reserved.