Investigation of cortisol levels in patients with anxiety disorders: a structured review.
Investigation of cortisol levels in patients with anxiety disorders: a structured review.
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DOI：
10.1007/7854_2014_299
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发表时间：
2014-01-01
影响因子：
--
通讯作者：
Baldwin, David S
中科院分区：
文献类型：
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作者：
Elnazer, Hesham Yousry;Baldwin, David S
焦虑症是一种常见的令人痛苦的疾病，通常出现在青春期或成年早期。他们可能会持续很多年，降低生活质量，限制学业和职业成就，并对相当大的经济压力负责。虽然有一系列心理和药物治疗可用，但它们的成功往往是有限的，许多患者长期受到与症状相关的重大残疾的困扰。每种焦虑症的详细病理生理机制尚未确定，仅基于目前对常规神经递质功能的了解的新疗法不太可能比现有疗法更有效或更好的耐受性。对恐慌症、广泛性焦虑症、特定恐惧症和社交焦虑症的下丘脑-垂体轴功能的调查得出了有趣的发现，但并未揭示内分泌障碍的一致模式，这可能反映了方法以及临床样本的性质和大小的差异。对于使用标准化方法进行调查和数据分析的大型前瞻性研究(164字)的需求持续存在。
Anxiety disorders are common and distressing medical conditions, which typically arise in adolescence or early adult life. They can persist for many years, reducing quality of life, limiting academic and occupational achievement, and being responsible for considerable economic pressures. Although a range of psychological and pharmacological treatments are available, their success is often limited, and many patients remain troubled by significant symptom-related disability for long periods. The detailed pathophysiology of each anxiety disorder is not established, and novel treatments that are based solely on current understanding of conventional neurotransmitter function are unlikely to be substantially more effective or better tolerated than current treatments. Investigations of hypothalamo-pituitary axis function across panic disorder, generalized anxiety disorder, specific phobias and social anxiety disorder have produced intriguing findings but not revealed a consistent pattern of endocrine disturbance, perhaps reflecting differences in methodology and the nature and size of the clinical samples. There is a persistent need for large, prospective studies using standardized methods for investigation and data analysis (164 words).