The activity of halofuginone in immunosuppressed rats infected with Cryptosporidium parvum.
The activity of halofuginone in immunosuppressed rats infected with Cryptosporidium parvum.
复制标题
卤常酮在感染小隐孢子虫的免疫抑制大鼠中的活性。
DOI：
10.1093/jac/35.3.391
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Rehg,JE
中科院分区：
文献类型：
--
作者：
Rehg,JE
Halofuginone was evaluated for its activity against experimentally induced infection due toCryptosporidium parvumin rats rendered immunosuppressed with dexamethasone. The drug'activity was dose-related and both prophylaxisand therapy reduced the rate and severity of infection in the small intestine and caecum. Prophylactic treatment reduced infection of the common bile duct, but therapeutic administration did not and neither form of treatment reduced the infection rate in the colon. Intestinal infection recurred at a level comparable to that of untreated controls when treatment was discontinued. Treatment with halofuginone may reduce the severity of acute cryptosporidiosis, but is less efficacious for chronic cryptosporidiosis involving the colon and extraintestinal tissues, a manifestation increasingly seen in the immunocompromised host.
