Extracellular matrix remodeling effects of serum amyloid A1 in the human amnion: Implications for fetal membrane rupture
Extracellular matrix remodeling effects of serum amyloid A1 in the human amnion: Implications for fetal membrane rupture
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DOI：
10.1111/aji.13073
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发表时间：
2018-12
影响因子：
3.6
通讯作者：
Yawei Wang;Wangsheng Wang;Luyao Wang;Yirong Bao;Jiangwen Lu;Yi Lu;Chuyue Zhang;Wenjiao Li;K. Sun;Hao Ying
中科院分区：
文献类型：
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作者：
Yawei Wang;Wangsheng Wang;Luyao Wang;Yirong Bao;Jiangwen Lu;Yi Lu;Chuyue Zhang;Wenjiao Li;K. Sun;Hao Ying
胎膜破裂是分娩时的一个关键事件，在此之前会发生广泛的细胞外基质（ECM）重塑。我们最近的研究表明，人类胎膜能够从头合成血清淀粉样蛋白A1（SAA1），一种急性期蛋白，并且SAA1在羊膜中的丰度在分娩时增加。然而，SAA1 在人类分娩中的确切作用仍有待确定。
Rupture of fetal membranes is a crucial event at parturition, which is preceded by extensive extracellular matrix (ECM) remodeling. Our recent studies have demonstrated that the human fetal membranes are capable of de novo synthesis of serum amyloid A1 (SAA1), an acute phase protein, and the abundance of SAA1 in the amnion was increased at parturition. However, the exact role of SAA1 in human parturition remains to be established.