Intrafollicular soluble RAGE benefits embryo development and predicts clinical pregnancy in infertile patients of advanced maternal age undergoing in vitro fertilization
Intrafollicular soluble RAGE benefits embryo development and predicts clinical pregnancy in infertile patients of advanced maternal age undergoing in vitro fertilization
复制标题
卵泡内可溶性 RAGE 有利于胚胎发育并预测接受体外受精的高龄不孕患者的临床妊娠
DOI：
10.1007/s11596-017-1722-z
复制
发表时间：
2017-04-01
影响因子：
--
通讯作者：
Liang, Xiao-yan
中科院分区：
文献类型：
--
作者：
Li, Yu-jie;Chen, Jian-hui;Liang, Xiao-yan
晚期糖基化终末产物的可溶性受体 (sRAGE) 可以诱骗有毒的 AGE，并被认为是一种保护因子。本研究旨在评估接受体外受精 (IVF) 的年轻或高龄不孕女性 (AMA) 的卵泡内 sRAGE 水平与临床结果之间的相关性。这项前瞻性研究共纳入了 62 名将接受 IVF 的年轻女性和 62 名 AMA 女性。测量卵泡内 sRAGE 浓度，以确定其分别与年轻女性和 AMA 女性中取出的卵母细胞、受精卵母细胞、高质量胚胎或临床妊娠的数量之间的关系。此外，还检查了 sRAGE 与年龄或卵泡刺激素 (FSH) 之间的相关性。我们发现年轻患者的滤泡内 sRAGE 水平高于 AMA 患者，表明 sRAGE 水平与年龄呈负相关。在年轻患者中，sRAGE 与取出的卵母细胞、受精卵母细胞、高质量胚胎或临床妊娠的成就没有相关性。但研究发现，获得更多卵母细胞、受精卵母细胞和高质量胚胎的 AMA 患者表现出更高的 sRAGE 水平，这是独立于年龄或 FSH 水平的临床妊娠的预后因素。总之，sRAGE 水平随着年龄的增长而降低。卵泡内 sRAGE 水平升高表明 AMA 女性具有良好的卵泡生长、受精和胚胎发育以及成功的临床妊娠，而在年轻女性中，sRAGE 的作用可能不那么重要。
Soluble receptor for advanced glycation end products (sRAGE) can decoy the toxic AGEs and is considered to be a protective factor. This study aimed to evaluate the correlation between intrafollicular sRAGE levels and clinical outcomes in infertile women of young or advanced maternal age (AMA) undergoing in vitro fertilization (IVF). A total of 62 young women and 62 AMA women who would undergo IVF were included in this prospective study. The intrafollicular sRAGE concentration was measured to determine its association with the number of retrieved oocytes, fertilized oocytes, high-quality embryos or achievement of clinical pregnancy in young and AMA women, respectively. Besides, correlations between sRAGE and age or follicle-stimulating hormone (FSH) were examined. We found that the intrafollicular sRAGE levels were higher in young patients than those in AMA patients, suggesting that the sRAGE levels were inversely correlated with age. In young patients, sRAGE showed no correlation with the number of retrieved oocytes, fertilized oocytes, high-quality embryos or achievement of clinical pregnancy. But it was found that AMA patients with more retrieved oocytes, fertilized oocytes and high-quality embryos demonstrated higher sRAGE levels, which were a prognostic factor for getting clinical pregnancy independent of age or FSH level. In conclusion, the sRAGE levels decrease with age. Elevated intrafollicular sRAGE levels indicate good follicular growth, fertilization and embryonic development, and successful clinical pregnancy in AMA women, while in young women, the role of sRAGE may not be so predominant.