Unraveling the complexity of mitochondrial complex I assembly: A dynamic process
Unraveling the complexity of mitochondrial complex I assembly: A dynamic process
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DOI：
10.1016/j.bbabio.2016.03.031
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发表时间：
2016-07-01
影响因子：
4.3
通讯作者：
Nijtmans, Leo
中科院分区：
文献类型：
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作者：
Sanchez-Caballero, Laura;Guerrero-Castillo, Sergio;Nijtmans, Leo
哺乳动物复合物I由44个不同的亚基组成，其组装需要至少13个特异性组装因子。线粒体呼吸链酶的正常功能对细胞存活至关重要，因为它主要参与能量产生和细胞信号传导。复合体I的组装依赖于几个关键过程的协调，这些过程需要通过许多组装因素紧密地相互联系和协调。对复杂I装配的理解从简单的顺序概念发展到描述复杂过程的更复杂的模块化装配模型。根据这个模型，不同的模块独立组装，然后相互结合形成最终的酶。在这篇综述中，我们的目标是解开复杂的I组装的复杂性，并在这个基本的和迷人的过程中提供最新的见解。本文是Volker Zickermann和Ulrich Brandt编辑的题为呼吸复合体I的特刊的一部分。(C)© 2016 Elsevier B.V.版权所有。
Mammalian complex I is composed of 44 different subunits and its assembly requires at least 13 specific assembly factors. Proper function of the mitochondrial respiratory chain enzyme is of crucial importance for cell survival due to its major participation in energy production and cell signaling. Complex I assembly depends on the coordination of several crucial processes that need to be tightly interconnected and orchestrated by a number of assembly factors. The understanding of complex I assembly evolved from simple sequential concept to the more sophisticated modular assembly model describing a convoluted process. According to this model, the different modules assemble independently and associate afterwards with each other to form the final enzyme. In this review, we aim to unravel the complexity of complex I assembly and provide the latest insights in this fundamental and fascinating process. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. (C) 2016 Elsevier B.V. All rights reserved.