Interfering with interferon receptor sorting and trafficking: Impact on signaling
Interfering with interferon receptor sorting and trafficking: Impact on signaling
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DOI：
10.1016/j.biochi.2007.03.014
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发表时间：
2007-06-01
期刊：
影响因子：
3.9
通讯作者：
Lamaze, Christophe
中科院分区：
文献类型：
--
作者：
Claudinon, Julie;Monier, Marie-Noelle;Lamaze, Christophe
干扰素及其受体在多种生物学功能中发挥着重要作用。许多文献和综述强调，JAK/STAT机制在IFN与其质膜上的同源受体结合后传递的信息中起着强制性的作用。相比之下，很少有研究涉及干扰素受体的内吞作用和细胞内转运，这是干扰素结合后的直接步骤。然而，最近的发现阐明了干扰素受体分类和贩运在控制干扰素信号传递方面的重要性。因此。干扰素受体可以包括在不断增长的信号受体家族中，对其生物活性的调节关键涉及内吞作用和运输(C)，2007年埃尔塞维尔·马森公司。版权所有。
Interferons (IFNs) and their receptors (IFN-Rs) play fundamental roles in a multitude of biological functions. Many articles and reviews emphasize that the JAK/STAT machinery is obligatory for relay of the information transmitted by IFNs after binding to their cognate receptors at the plasma membrane. In contrast, very few studies have addressed the endocytosis and the intracellular trafficking of IFN-Rs, the immediate step following IFN binding. However, recent findings have shed light on the importance of IFN-R sorting and trafficking in the control of IFN signaling. Thus. IFN-Rs can be included in the growing family of signaling receptors for which regulation of biological activity critically involves endocytosis and trafficking, (C) 2007 Elsevier Masson SAS. All rights reserved.