Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension
Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension
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DOI：
10.1002/ejhf.177
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发表时间：
2015-01-01
影响因子：
18.2
通讯作者：
Shah, Amil M.
中科院分区：
文献类型：
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作者：
Roca, Gabriela Querejeta;Campbell, Patricia;Shah, Amil M.
目的由于肺动脉高压 (PAH) 与显着的发病率和死亡率相关，特别是在右心室 (RV) 功能障碍的患者中，我们的目的是确定减少肺血管阻力 (PVR) 的治疗对 PAH 中 RV 和 LV 变形的影响。 方法和结果 在随机分组的 68 名晚期 PAH 患者中，在基线、第 12 周和第 24 周测量了右心室游离壁纵向应变 (FWLS) 和左心室整体周向应变 (CS)。伊马替尼治疗肺动脉高压的随机疗效研究 (IMPRES) 试验中使用伊马替尼或安慰剂，并与 30 名健康对照者进行比较。与对照组相比，PAH 与 RV FWLS 受损相关（分别为 -15.95.4 与 -30.84.3；P
AimsAs pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, particularly among patients with right ventricular (RV) dysfunction, we aimed to determine the impact of therapy to reduce pulmonary vascular resistance (PVR) on RV and LV deformation in PAH.Methods and resultsRight ventricular free wall longitudinal strain (FWLS) and LV global circumferential strain (CS) were measured at baseline, 12 weeks, and 24 weeks in 68 patients with advanced PAH randomized to imatinib or placebo in the Imatinib in Pulmonary arterial hypertension, a Randomized Efficacy Study (IMPRES) trial, and compared with 30 healthy controls. Compared with controls, PAH was associated with impaired RV FWLS (-15.95.4 vs. -30.84.3, respectively; P