ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.
ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.
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DOI：
10.1016/j.bbamcr.2012.12.007
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Sawyer DB
中科院分区：
文献类型：
--
作者：
Pentassuglia L;Sawyer DB
神经调节蛋白(Nrg)/ErbB和整合素信号通路对胚胎和成人心脏的正常功能至关重要。这两个系统激活了几个下游信号通路，具有不同的生理输出：细胞存活、纤维化、兴奋-收缩耦合、肌丝结构、细胞-细胞和细胞-基质相互作用。Nrg1β在心肌细胞中激活ErbB2或其在癌细胞中的过表达可诱导FAK （Focal Adhesion Kinase）在特定位点的磷酸化，从而调节存活、侵袭和细胞间接触。FAK也是整合素受体的重要介质，将细胞外基质改变转化为细胞内信号。系统性FAK缺失是致命的，与左心室不致密相关，而成人心脏限制则是耐受良好的。然而，这些心脏更容易受到压力的影响，比如主动脉收缩、肥厚和缺血性损伤。由于FAK是下游的，并被整合素和Nrg-1β特异性激活，在这里，我们将探讨FAK在心脏中的作用，作为一种保护因子，并可能作为ErbB和整合素受体之间串扰的中介。
Neuregulin(Nrg)/ErbB and integrin signaling pathways are critical for the normal function of the embryonic and adult heart. Both systems activate several downstream signaling pathways, with different physiological outputs: cell survival, fibrosis, excitation-contraction coupling, myofilament structure, cell-cell and cell-matrix interaction. Activation of ErbB2 by Nrg1β in cardiomycytes or its overexpression in cancer cells induces phosphorylation of FAK (Focal Adhesion Kinase) at specific sites with modulation of survival, invasion and cell-cell contacts. FAK is also a critical mediator of integrin receptors, converting extracellular matrix alterations into intracellular signaling. Systemic FAK deletion is lethal and is associated with left ventricular non-compaction whereas cardiac restriction in adult hearts is well tolerated. Never the less, these hearts are more susceptible to stress conditions like trans-aortic constriction, hypertrophy, and ischemic injury. As FAK is both downstream and specifically activated by integrins and Nrg-1β, here we will explore the role of FAK in the heart as a protective factor and as possible mediator of the crosstalk between the ErbB and Integrin receptors.
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DOI：
10.1083/jcb.200911110
发表时间：
2010-07-26
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chao WT;Daquinag AC;Ashcroft F;Kunz J
通讯作者：
Kunz J
影响因子：
4.7
作者：
Agouni, Abdelali;Sourbier, Carole;Massfelder, Thierry
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DOI：
10.1152/ajpheart.00534.2001
发表时间：
2002-02-01
影响因子：
4.8
作者：
Domingos, PP;Fonseca, PM;Franchini, KG
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Franchini, KG
DOI：
10.1152/ajpheart.1999.277.5.h2026
发表时间：
1999-11-01
影响因子：
4.8
作者：
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通讯作者：
Kelly, RA
DOI：
10.1161/atvbaha.112.245134
发表时间：
2012-04
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Cheng Z;DiMichele LA;Hakim ZS;Rojas M;Mack CP;Taylor JM
通讯作者：
Taylor JM