NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway
NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway
复制标题
DOI：
10.1016/j.bbrep.2019.100722
复制
发表时间：
2020-03-01
影响因子：
2.7
通讯作者：
Tanaka, Kazuo
中科院分区：
文献类型：
--
作者：
Ishikawa, Hiroki;Ino, Satoshi;Tanaka, Kazuo
Norovirus infection cause epidemic nonbacterial gastroenteritis in patients. The immune mechanisms responsible for the clearance of virus are not completely understood. We examined whether NKT cells are effective against norovirus infection using CD1d KO mice. The body weights of 4-weeks-old CD1d KO mice that were infected with murine norovirus-S7 (MNV-S7) were significantly lower than those of non-infected CD1d KO mice. On the other hand, the body weights of infected WT mice were comparable to those of non-infected WT mice. Correspondingly, CD1d KO mice had an almost 1000-fold higher MNV-S7 burden in the intestine after infection in comparison to WT mice. The mechanism responsible for the insufficient MNV-S7 clearance in CD1d KO mice was attributed to reduced IFN-gamma production early during MNV-S7 infection. In addition, the markedly impaired IL-4 production in CD1d KO mice resulted in an impaired MNV-S7-specific secretory IgA production after MNV-S7 infection which is associated with mucosal immunity. Thus, the present results provide evidence that NKT cells play an essential role in MNV-S7 clearance.
