SINGLE-TRIAL CONDITIONED PLACE PREFERENCE USING INTRAVENOUS MORPHINE
SINGLE-TRIAL CONDITIONED PLACE PREFERENCE USING INTRAVENOUS MORPHINE
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DOI：
10.1016/0091-3057(86)90092-4
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发表时间：
1986-11-01
影响因子：
3.6
通讯作者：
NEISEWANDER, JL
中科院分区：
文献类型：
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作者：
BARDO, MT;NEISEWANDER, JL
本实验研究了大鼠单次静脉注射吗啡后的条件性位置偏爱（CPP）。当吗啡（8 mg/kg）与明显的白色隔室配对15或30分钟时，获得单次试验CPP。当吗啡给药延迟15或25分钟后开始的30分钟暴露于白色室，单次试验CPP没有得到。在暴露于含有吗啡的白色隔室30分钟后15分钟，静脉注射纳洛酮（2 mg/kg）也阻断了单次试验CPP，但纳洛酮本身并没有改变位置偏好。从这些实验的结果表明，单次试验CPP使用静脉注射吗啡可以提供一个有用的动物模型，以评估初始的药物经验的增强效果。
Experiments were performed to investigate single-trail conditioned place preference (CPP) using intravenous morphine in rats. Single-trial CPP was obtained when morphine (8 mg/kg) was paired for either 15 or 30 min with a distinct white compartment. When morphine administration was delayed for either 15 or 25 min after the beginning of a 30-min exposure to the white compartment, single-trial CPP was not obtained. Intravenous naloxone (2 mg/kg) also blocked single-trial CPP when administered 15 min after the beginning of the 30-min exposure to the white compartment with morphine, but naloxone by itself did not alter place preference. The results from these experiments indicate that single-trial CPP using intravenous morphine may offer a useful animal model to assess the reinforcing efficacy of the initial drug experience.