Clinical characteristics of 194 cases of COVID-19 in Huanggang and Taian, China
Clinical characteristics of 194 cases of COVID-19 in Huanggang and Taian, China
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DOI：
10.1007/s15010-020-01440-5
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发表时间：
2020-05-10
期刊：
影响因子：
7.5
通讯作者：
Yue, Maokui
中科院分区：
文献类型：
--
作者：
Zhang, Hong;Shang, Wenli;Yue, Maokui
目的分析湖北黄冈和山东泰安两地194例新型冠状病毒病（COVID-19）的临床特征。方法回顾性调查2020年1月22日至2月28日在黄冈市中心医院和山东第一医科大学第二附属医院确诊的COVID-19病例的临床、实验室特征和CT影像学资料。采用真实的时间PCR检测呼吸道标本中的新型冠状病毒。免疫组化法检测组织中ACE 2的表达。结果194例COVID-19感染者中，男性108例，中位年龄48.3岁。平均临床前时间为7.44天。157名患者中，除37名重症或危重症患者外，其余患者均表现出轻度或中度症状。三次核酸检测确诊190例，确诊率为97.94%。临床症状以发热、咽痛、咳嗽为主，分别占75.26%、50.52%和44.33%。肝功能异常30例（15.46%）。影像学检查显示141例（72.68%）双肺实质异常密度影，53例（27.32%）双肺实质无明显异常。截至目前，累计出院109例，死亡9例。ACE 2在重症和危重症患者中表达上调。结论COVID-19的诊断应结合临床症状、实验室检查和CT影像学检查进行综合分析。ACE 2可能是COVID-19的受体。
Purpose We aimed to report the clinical characteristics of 194 cases coronavirus disease-19 (COVID-19) in Huanggang, Hubei and Taian, Shandong. Methods We retrospectively investigated the clinical, laboratory characteristics and CT imaging of confirmed cases of COVID-19 from January 22 to February 28, 2020 in Huanggang Central Hospital and The Second Affiliated Hospital of Shandong First Medical University. Real time PCR was used to detect the new coronavirus in respiratory samples. Immunohistochemical staining was used to detect the expressions of ACE2 in tissues. Results Among the 194 patients infected with COVID-19, 108 patients were male, with a median age of 48.3 years. The average preclinical period was 7.44 day. Except for 37 severe or critically ill patients, the rest of the 157 patients exhibited mild or moderate symptoms. 190 (97.94%) patients were confirmed during the three times nucleic acid test. The main clinical symptom of the patients were fever, sore throat and cough, which accounted for 146 cases (75.26%), 98 (50.52%) and 86 cases (44.33%), respectively. 30 patients (15.46%) showed liver dysfunction. Imaging examination showed that 141 patients (72.68%) showed abnormal density shadow, while 53 cases (27.32%) had no obvious abnormality in the parenchyma of both lungs. Up to now, 109 cases have been discharged from the hospital, and 9 patients died. The ACE2 expression levels were up-regulated in patients of severe type and critically ill type. Conclusion Clinical symptoms, laboratory tests and CT imaging should be combined for comprehensive analysis to diagnose COVID-19. ACE2 may be the receptor of COVID-19.