A Study of Eclampsia Cases Associated with Posterior Reversible Encephalopathy Syndrome
A Study of Eclampsia Cases Associated with Posterior Reversible Encephalopathy Syndrome
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DOI：
10.7860/jcdr/2015/14039.6276
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发表时间：
2015-07-01
影响因子：
0.2
通讯作者：
Shruthi, K. R.
中科院分区：
文献类型：
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作者：
Bembalgi, Shobha;Kamate, Vishal;Shruthi, K. R.
目的：在发达国家，子痫的发病率为1/2000至3250例分娩，在印度为1 - 5%。可逆性后部脑病综合征（PRES）是由可逆性脑缺血引起的一系列症状，主要发生在大脑后部血管。PRES与先兆子痫和急性肾损伤有关.我们提出了一项研究，其中子痫并发PRES的患者。我们的目的是研究临床放射学资料，相关的并发症和子痫伴PRES患者的结局。材料和方法：一项回顾性研究对2010年8月至2014年7月四年内所有诊断为子痫伴PRES综合征的妊娠进行了回顾性研究，该研究由卡纳塔克邦医学科学研究所管理，胡布利，印度。在研究期间，在该机构分娩的36，094名患者中，有11名患者患有子痫伴PRES综合征。其中9例为初产妇，8例为20-25岁年龄组，10例表现为多次发作。8例患者的癫痫发作仅用MgSO 4控制。三名患者出现围产期死亡。结论：在卡纳塔克邦医学科学研究所分娩的患者中，子痫伴PRES综合征的发病率为0.03%。PRES的发病率在产后子痫病例中高于产前子痫。PRES多见于初产妇和年轻组（20 ~ 25岁）。先兆子痫的症状如头痛、上腹痛和视力模糊在这些患者中并不常见。在大多数患者中，单独用MgSO控制癫痫发作。合并PRES的子痫患者预后良好。
Objectives: Incidence of eclampsia is 1 in 2000 to 3250 deliveries in developed countries and 1 to 5% in India. Posterior reversible encephalopathy syndrome (PRES) is a constellation of symptoms caused by reversible ischaemia mostly of the posterior cerebral vasculature. PRES has been associated with preeclampsiaeclampsia and acute renal injury. We present a study of patients in whom eclampsia was complicated with PRES. Our aim was to study the clinico-radiological profile, associated complications and outcome of patients who had eclarnpsia with PRES. Materials andMethods: A retrospective study was done of all pregnancies diagnosed as eclampsia with PRES syndrome over a four year period from August 2010 to July 2014 managed at Karnataka institute of medical sciences, Hubli, India.Results: Eleven patients had eclampsia with PRES syndrome of the 36,094 patients delivered in the institution over the study period. Nine of these were primigravidas, 8 were of 20-25 years age group, 10 presented with multiple seizure episodes. In eight patients seizures were controlled only with MgSo4. Perinatal mortality was seen in three patients. There were no maternal deaths in these cases.Conclusion: Incidence of eclampsia with PRES syndrome was 0.03% amongst the patients delivered in Karnataka institute of medical sciences. The incidence of PRES was more amongst cases of postpartum eclampsias as compared to anteparturn eclampsias. PRES was more common in primigravidas and younger age group (20 to 25 years). Signs of imminent eclampsia like headache, epigastric pain and blurring vision were uncommon in these patients. In the majority of the patients seizures were controlled with MgSo, alone. Prognosis of eclamptic patients with PRES was favourable.