[A nationwide survey of patients with Bickerstaff brainstem encephalitis: diversity of underlying mechanism].
[A nationwide survey of patients with Bickerstaff brainstem encephalitis: diversity of underlying mechanism].
复制标题
[全国范围内比克斯塔夫脑干脑炎患者的调查：潜在机制的多样性]。
DOI：
10.5692/clinicalneurol.53.1322
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
M. Koga
中科院分区：
文献类型：
--
作者：
M. Koga
Bickerstaff脑干脑炎（BBE）的特征是急性进行性双侧眼球轻瘫和共济失调伴意识障碍或锥体束征，或两者兼而有之;所有这些都是随后恢复良好的双相过程。与格林-巴利综合征（GBS）一样，BBE被认为具有由先前感染触发的自身免疫机制。作者在日本进行的全国范围的BBE流行病学调查表明，BBE由典型和非典型病例组成。典型BBE具有与Fisher综合征相似的神经学和血清学特征，并且显示良好的恢复，而非典型BBE的特征在于延迟恢复、阴性抗GQ 1b抗体、异常脑脊液和脑MRI结果以及其他可能的病因。
Bickerstaff brainstem encephalitis (BBE) is characterized by acutely progressive bilateral ophthalmoparesis and ataxia with impaired consciousness or pyramidal signs, or both; all of which are followed by a monophasic course with good recovery. Alike Guillain-Barré syndrome (GBS), BBE is proposed to have an autoimmune mechanism triggered by antecedent infection. The nationwide epidemiologic survey for BBE, which the author had performed in Japan, suggests that BBE consists of typical and atypical cases. Typical BBE has similar neurological and serological features to Fisher syndrome and shows good recovery, whereas atypical BBE is characterized by delayed recovery, negative anti-GQ1b antibodies, and abnormal cerebrospinal fluid and brain MRI findings with other possible pathogeneses.