Childhood-Onset Disease as a Predictor of Mortality in an Adult Cohort of Patients With Systemic Lupus Erythematosus
Childhood-Onset Disease as a Predictor of Mortality in an Adult Cohort of Patients With Systemic Lupus Erythematosus
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DOI：
10.1002/acr.20179
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发表时间：
2010-08-01
影响因子：
4.7
通讯作者：
Yelin, Edward
中科院分区：
文献类型：
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作者：
Hersh, Aimee O.;Trupin, Laura;Yelin, Edward
Objective.在一组成人系统性红斑狼疮（SLE）患者中，研究儿童期发病疾病对死亡率的预测作用。数据来源于加州大学狼疮结局研究，该研究是一项纵向队列研究，包括957例成人SLE受试者，其中包括98例儿童期发病的SLE受试者。基线和随访数据通过2002-2007年进行的电话访谈获得。确定5年随访期间的死亡人数，并计算队列和各年龄组的标准化死亡率比（SMR）。Kaplan-Meier生命表分析用于比较儿童期-（定义为SLE诊断）
Objective. To examine childhood-onset disease as a predictor of mortality in a cohort of adult patients with systemic lupus erythematosus (SLE).Methods. Data were derived from the University of California Lupus Outcomes Study, a longitudinal cohort of 957 adult subjects with SLE that includes 98 subjects with childhood-onset SLE. Baseline and followup data were obtained via telephone interviews conducted in 2002-2007. The number of deaths during 5 years of followup was determined and standardized mortality ratios (SMRs) for the cohort, and across age groups, were calculated. Kaplan-Meier life table analysis was used to compare mortality rates between childhood- (defined as SLE diagnosis at