How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals
How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals
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DOI：
10.1179/096805105x76850
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发表时间：
2005-12-01
期刊：
影响因子：
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通讯作者：
Girardin, SE
中科院分区：
文献类型：
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作者：
Fritz, JH;Girardin, SE
病原体的先天免疫检测依赖于称为模式识别分子 (PRM) 的特定类别的微生物传感器。在哺乳动物中，此类 PRM 包括 Toll 样受体 (TLR) 以及属于 Nod 样受体 (NLR) 家族的细胞内蛋白 NOD1 和 NOD2。在过去十年中，随着这些分子的发现，大多数分子都被赋予了先天免疫功能，并且对于大多数分子来说，这些分子检测到的微生物基序已被识别。先天免疫的下一个挑战是更好地理解不同 PRM 同时诱导的信号通路之间复杂的相互作用，以及这如何影响定制一线反应和诱导针对特定病原体的适应性免疫。
Innate immune detection of pathogens relies on specific classes of microbial sensors called pattern-recognition molecules (PRM). In mammals, such PRM include Toll-like receptors (TLRs) and the intracellular proteins NOD1 and NOD2, which belong to the family of Nod-like receptors (NLRs). Over the last decade as these molecules were discovered, a function in innate immunity has been assigned for the majority of them and, for most, the microbial motifs that these molecules detect were identified. One of the next challenges in innate immunity is to establish a better understanding of the complex interplay between signaling pathways induced simultaneously by distinct PRMs and how this affects tailoring first-line responses and the induction of adaptive immunity to a given pathogen.