Amygdala connectivity and implications for social cognition and disorders.
Amygdala connectivity and implications for social cognition and disorders.
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DOI：
10.1016/b978-0-12-823493-8.00017-1
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发表时间：
2022
影响因子：
--
通讯作者：
Chang, Steve W C
中科院分区：
文献类型：
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作者：
Meisner, Olivia C;Nair, Amrita;Chang, Steve W C
杏仁核是皮质下的枢纽区域，在各种情感和动机相关行为中至关重要。虽然早期研究对我们了解该区域与其他皮质下和皮质区域的广泛联系做出了重大贡献，但最近的方法论进展使研究人员能够更好地了解这些回路的细节及其行为贡献。这项工作的大部分重点是研究杏仁核回路在社会认知中的作用。在本章中，我们回顾了关于杏仁核结构、功能和社会认知参与的长期知识和新颖研究。我们特别关注杏仁核与内侧前额皮质、眶额皮质和海马体的回路，因为这些区域与杏仁核有着广泛的解剖和功能联系。此外，我们还讨论了杏仁核功能障碍如何导致临床疾病（包括自闭症谱系障碍、社交焦虑症和威廉姆斯综合症）的社交缺陷。我们得出的结论是，杏仁核介导的社会功能是通过杏仁核与其互连的大脑区域之间的多种复杂相互作用来协调的，这证实了从网络角度理解杏仁核的重要性。
The amygdala is a hub subcortical region that is crucial in a wide array of affective and motivation related behaviors. While early research contributed significantly to our understanding of this region’s extensive connections to other subcortical and cortical regions, recent methodological advances have enabled researchers to better understand the details of these circuits and their behavioral contributions. Much of this work has focused specifically on investigating the role of amygdala circuits in social cognition. In this chapter, we review both longstanding knowledge and novel research on the amygdala’s structure, function, and involvement in social cognition. We focus specifically on the amygdala’s circuits with the medial prefrontal cortex, the orbitofrontal cortex, and the hippocampus, as these regions share extensive anatomic and functional connections with the amygdala. Furthermore, we discuss how dysfunction in the amygdala may contribute to social deficits in clinical disorders including Autism Spectrum Disorder, Social Anxiety Disorder, and Williams Syndrome. We conclude that social functions mediated by the amygdala is orchestrated through multiple intricate interactions between the amygdala and its interconnected brain regions, endorsing the importance of understanding the amygdala from network perspectives.