Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project
Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project
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DOI：
10.1111/mcn.12049
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发表时间：
2015-12-01
影响因子：
3.4
通讯作者：
Dewey, Kathryn G.
中科院分区：
文献类型：
--
作者：
Arimond, Mary;Zeilani, Mamane;Dewey, Kathryn G.
国际脂质营养补充剂 (iLiNS) 项目于 2009 年启动，旨在为脂质营养补充剂 (LNS) 预防弱势群体营养不良的潜力提供证据基础。第一个项目目标是为 6-24 个月婴儿以及孕妇和哺乳期妇女开发可接受的 LNS 产品，用于三个国家（布基纳法索、加纳和马拉维）的研究。本文分享了补充剂配方和设计中一系列决策的基本原理，包括与日粮量、成分、营养成分、安全和质量以及包装相关的决策。大多数 iLiNS 补充剂的每日定量为 20 克，用于家庭强化当地饮食。对于婴儿来说，这种口粮量的目的是避免母乳流失，并允许饮食多样化，包括任何当地可获得的营养丰富的食物。成分的选择取决于风味、微量营养素、抗营养素和必需脂肪酸含量的可接受性。旨在预防营养不良的 LNS 的营养成分反映了这样一种可能性：在许多资源匮乏的环境中，营养最脆弱的个体（婴儿、幼儿、孕妇和哺乳期妇女）的饮食可能缺乏多种微量营养素，并且可能缺乏必需脂肪酸。在原料采购和 LNS 生产过程中，需要采取安全和质量控制程序，以防止毒素或病原体污染，并确保产品随着时间的推移保持稳定和适口。包装设计决策必须考虑产品保护、稳定性、便利性和份量控制。
The International Lipid-Based Nutrient Supplements (iLiNS) Project began in 2009 with the goal of contributing to the evidence base regarding the potential of lipid-based nutrient supplements (LNS) to prevent undernutrition in vulnerable populations. The first project objective was the development of acceptable LNS products for infants 6-24 months and for pregnant and lactating women, for use in studies in three countries (Burkina Faso, Ghana and Malawi). This paper shares the rationale for a series of decisions in supplement formulation and design, including those related to ration size, ingredients, nutrient content, safety and quality, and packaging. Most iLiNS supplements have a daily ration size of 20 g and are intended for home fortification of local diets. For infants, this ration size is designed to avoid displacement of breast milk and to allow for dietary diversity including any locally available and accessible nutrient-dense foods. Selection of ingredients depends on acceptability of flavour, micronutrient, anti-nutrient and essential fatty acid contents. The nutrient content of LNS designed to prevent undernutrition reflects the likelihood that in many resource-poor settings, diets of the most nutritionally vulnerable individuals (infants, young children, and pregnant and lactating women) are likely to be deficient in multiple micronutrients and, possibly, in essential fatty acids. During ingredient procurement and LNS production, safety and quality control procedures are required to prevent contamination with toxins or pathogens and to ensure that the product remains stable and palatable over time. Packaging design decisions must include consideration of product protection, stability, convenience and portion control.