Diverse roles of FOXO family members in gastric cancer.
Diverse roles of FOXO family members in gastric cancer.
复制标题
FOXO家族成员在胃癌中的不同作用。
DOI：
10.4251/wjgo.v13.i10.1367
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发表时间：
2021-10-15
影响因子：
3
通讯作者：
Wu HT
中科院分区：
文献类型：
--
作者：
Chen YH;Li CL;Chen WJ;Liu J;Wu HT
胃癌（GC）是世界范围内第五大诊断癌症和第三大癌症相关死亡原因。尽管在诊断、手术切除、全身化疗和免疫治疗方面取得了进展，但胃癌患者的预后仍然很差。晚期胃癌患者的总体5年生存率低于5%。FOXO亚家族是转录因子的叉头盒家族，由FOXO 1、FOXO 3、FOXO 4和FOXO 6四个成员组成。该亚家族在正常组织和恶性肿瘤中的许多细胞过程中起重要作用，例如细胞周期、细胞生长、凋亡、自噬、应激抗性、免于聚集毒性的保护、DNA修复、肿瘤抑制和代谢。基于FOXO抑制血管生成和转移以及促进细胞凋亡的能力，各种研究支持FOXO作为肿瘤抑制剂的作用，但其他几项研究表明，FOXO在某些情况下也可能促进肿瘤进展。为了阐明FOXO在GC中的不同作用，本文系统地综述了FOXO在GC中的细胞功能，以确定GC患者的潜在治疗靶点和治疗策略。
Gastric cancer (GC) is the fifth most diagnosed cancer and the third leading cause of cancer-related death worldwide. Although progress has been made in diagnosis, surgical resection, systemic chemotherapy, and immunotherapy, patients with GC still have a poor prognosis. The overall 5-year survival rate in patients with advanced GC is less than 5%. The FOXO subfamily, of the forkhead box family of transcription factors, consists of four members, FOXO1, FOXO3, FOXO4, and FOXO6. This subfamily plays an important role in many cellular processes, such as cell cycle, cell growth, apoptosis, autophagy, stress resistance, protection from aggregate toxicity, DNA repair, tumor suppression, and metabolism, in both normal tissue and malignant tumors. Various studies support a role for FOXOs as tumor suppressors based on their ability to inhibit angiogenesis and metastasis, and promote apoptosis, yet several other studies have shown that FOXOs might also promote tumor progression in certain circumstances. To elucidate the diverse roles of FOXOs in GC, this article systematically reviews the cellular functions of FOXOs in GC to determine potential therapeutic targets and treatment strategies for patients with GC.
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