Structure and polymorphism of the HLA class II SB light chain genes.
Structure and polymorphism of the HLA class II SB light chain genes.
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HLA II 类 SB 轻链基因的结构和多态性。
DOI：
10.1002/j.1460-2075.1984.tb02245.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Strominger,JL
中科院分区：
文献类型：
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作者：
Kappes,DJ;Arnot,D;Okada,K;Strominger,JL
HLA II类区域至少包含三组位点：DR、DC和SB，它们在免疫反应中发挥重要作用。这些位点编码的抗原是由α链和β链组成的异二聚体。报道了完整的 II 类 β cDNA 克隆的序列，其序列与 SB β 链可用的有限 N 端蛋白质序列非常一致。此外，还获得了两种不同SB单倍型的基因组SBβ克隆的结构和编码序列，并允许定义一些多态性区域。 SB beta 基因似乎在其 3' 末端经历了交替剪接，导致两个不同的胞质内区域的表达。第二个非等位基因 SB beta 样基因 SX beta 的部分测序表明它是一个假基因。
The HLA Class II region contains at least three groups of loci, DR, DC and SB, which play an important role in the immune response. The antigens encoded at these loci are heterodimers composed of an alpha and a beta chain. The sequence of a complete Class II beta cDNA clone whose sequence agrees closely with the limited N‐terminal protein sequence available for the SB beta chain is reported. In addition the structure and coding sequence of genomic SB beta clones of two different SB haplotypes has been obtained and allows definition of some polymorphic regions. The SB beta gene appears to undergo alternate splicing at its 3′ end, resulting in expression of two different intracytoplasmic regions. Partial sequencing of a second non‐allelic SB beta‐like gene, SX beta, indicates that it is a pseudogene.