Effect of Brimonidine on Retinal Vascular Autoregulation and Short-term Visual Function in Normal Tension Glaucoma
Effect of Brimonidine on Retinal Vascular Autoregulation and Short-term Visual Function in Normal Tension Glaucoma
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DOI：
10.1016/j.ajo.2014.03.015
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发表时间：
2014-07-01
影响因子：
4.2
通讯作者：
Pasquale, Louis R.
中科院分区：
文献类型：
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作者：
Feke, Gilbert T.;Bex, Peter J.;Pasquale, Louis R.
目的：评估 0.15% 溴莫尼定是否会改变视网膜血管失调的正常眼压青光眼患者的视网膜血管自动调节和短期视功能。设计：非随机临床试验。方法：在这项前瞻性研究中，46 名之前未接受溴莫尼定治疗的正常眼压青光眼患者接受了视网膜血管自动调节测试，并使用倍频技术视野检查和等效噪声运动进行视功能评估敏感性测试。我们测量了受试者坐着然后躺着 30 分钟的主要颞视网膜动脉的血流量。视网膜血流变化伴随姿势变化超出之前在健康受试者中发现的范围的患者被归类为视网膜血管失调。他们接受 0.15% 溴莫尼定治疗 8 周，并指定进行重新测试。 结果：23 名患者在初次就诊时表现出视网膜血管失调。年龄较小 (P = .050) 和糖尿病 (P = .055) 是视网膜血管失调的略微显着的危险因素。经过 8 周的溴莫尼定疗程后，完成研究的 17 名患者中有 14 名显示姿势引起的视网膜血流变化恢复到与正常视网膜血管自动调节一致的水平 (P < .0001)。我们发现使用溴莫定治疗后，倍频技术视野检查或运动检测参数没有显着变化（所有测试的 P > .09）。结论：溴莫定显着改善正常眼压青光眼患者受损的视网膜血管自动调节功能，但无法证明视觉功能的短期改变。 (C) 2014 年，Elsevier Inc. 保留所有权利。）
PURPOSE: To assess whether brimonidine 0.15% alters retinal vascular autoregulation and short-term visual function in normal tension glaucoma patients who demonstrate retinal vascular dysregulation.DESIGN: Nonrandomized clinical trial.METHODS: In this prospective study, 46 normal tension glaucoma patients not previously treated with brimonidine underwent retinal vascular autoregulation testing and visual function assessment using frequency doubling technology perimetry and equivalent noise motion sensitivity testing. We measured blood flow in a major temporal retinal artery with subjects seated and then while reclined for 30 minutes. Patients having a change in retinal blood flow with posture change outside the range previously found in healthy subjects were classified as having retinal vascular dysregulation. They were treated with brimonidine 0.15% for 8 weeks and designated for retesting.RESULTS: Twenty-three patients demonstrated retinal vascular dysregulation at the initial visit. Younger age (P = .050) and diabetes (P = .055) were marginally significant risk factors for retinal vascular dysregulation. After the 8-week course with brimonidine, 14 of the 17 patients who completed the study showed a return of posture-induced retinal blood flow changes to levels consistent with normal retinal vascular autoregulation (P < .0001). We found no significant changes in frequency doubling technology perimetry or in motion detection parameters following treatment with brimondine (P > .09 for all tests performed).CONCLUSIONS: Brimonidine significantly improved impaired retinal vascular autoregulation in normal tension glaucoma patients, but short-term alteration in visual function could not be demonstrated. (C) 2014 by Elsevier Inc. All rights reserved.)