PH response behavior of giant vesicles comprised of amphiphilic poly(methacrylic acid)-block-poly(methyl methacrylate-random-mathacrylic acid)
PH response behavior of giant vesicles comprised of amphiphilic poly(methacrylic acid)-block-poly(methyl methacrylate-random-mathacrylic acid)
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两亲性聚(甲基丙烯酸)-嵌段-聚(甲基丙烯酸甲酯-无规-甲基丙烯酸)巨型囊泡的PH响应行为
DOI：
10.1007/s00396-014-3482-7
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Eri Yoshida
中科院分区：
文献类型：
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作者：
Izabela Rzeznicka;Hideyuki Horino;Nobuaki Kikkawa,Suguru Sakaguchi,Akihiro Morita;Satoshi Takahashi,Tadahiro Komeda;Hiroshi Fukumura;Taro Yamada;Maki Kawai;Eri Yoshida;Eri Yoshida;Eri Yoshida;Eri Yoshida;Eri Yoshida;Eri Yoshida;Eri Yoshida;Eri Yoshida
研究了由两亲性聚甲基丙烯酸-嵌段-聚甲基丙烯酸甲酯-无规甲基丙烯酸组成的微囊泡的pH依赖性转化，以探索将微囊泡作为人工生物膜模型的可能性.在甲醇水溶液中通过光聚合诱导的自组装制备的囊泡在pH 7.1的水中时保持其球形形状和大小。囊泡被破坏的pH值的增加，并最终解离成胶束在pH值12.8。通过将pH降低至7.5来重建囊泡;然而，由于中和过程中产生的盐的相互聚集，它们具有膜状形态。当置于甲醇水溶液中时，膜状形态转化为球形囊泡。重构的球形囊泡包括出芽囊泡和手形囊泡，表明球形囊泡是通过出芽分离和双层-杆状转变形成的。
The pH-dependent transformation of micro-sized giant vesicles comprised of amphiphilic poly(methacrylic acid)-block-poly(methyl methacrylate-random-methacrylic acid) was investigated in order to explore the possibility of using the giant vesicles as artificial models of biomembranes. The vesicles prepared by the photopolymerization-induced self-assembly in an aqueous methanol solution retained their spherical shape and size when placed in water at pH 7.1. The vesicles were disrupted by a pH increase and finally dissociated into micelles at pH 12.8. The vesicles were reconstructed by decreasing the pH to 7.5; however, they had a film-like morphology due to the interaggregation by the salt generated during the neutralization process. The film-like morphology was transformed into spherical vesicles when placed in an aqueous methanol solution. The reconstructed spherical vesicles included budding and hand-shaped vesicles, indicating that spherical vesicles were formed by the budding separation and by way of a bilayer-rod transition.