The mechanism of myocardial hypertrophy regulated by the interaction between mhrt and myocardin
The mechanism of myocardial hypertrophy regulated by the interaction between mhrt and myocardin
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MHRT与心肌素相互作用调控心肌肥厚的机制
DOI：
10.1016/j.cellsig.2017.11.007
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发表时间：
2018-03-01
影响因子：
4.8
通讯作者：
Zhang, Tongcun
中科院分区：
文献类型：
--
作者：
Luo, Ying;Xu, Yao;Zhang, Tongcun
作为含有 CarG 盒的启动子的强反式激活因子，心肌素对于心肌程序至关重要，并且是正常心脏发生所必需的。因此，它可能代表了心脏肥大和衰竭情况下可行的治疗生物标志物。近年来，通过心肌素调节心肌肥厚的研究十分普遍，其分子机制也越来越明确。在这里，我们揭示了 mhrt 和心肌素之间的一种相互作用，显示为调节心脏肥大的反馈调节机制。即IncRNA mhrt可以影响HDAC5对心肌素的乙酰化，从而抑制心肌素诱导的心脏肥大。此外，myocardin还可以通过与CarG盒结合直接激活mhrt转录。由此可见，mhrt和心肌素在心脏肥大过程中形成调节环路。这一发现可能对揭示心脏肥大的完整机制发挥积极作用。
As a strong transactivator of promoters containing CarG boxes, myocardin was critical for the cardiac muscle program and necessary for normal cardiogenesis. So it probably represents a viable therapeutic biomarker in the setting of cardiac hypertrophy and failure. In recent years, the studies of regulation of cardiac hypertrophy via myocardin are so common, and the molecular mechanism is becoming more and more clear. Here, we have revealed a kind of interaction between mhrt and myocardin shown as a feedbadk regulatory mechanism in the regulation of cardiac hypertrophy. That is, the IncRNA mhrt can affect the acetylation of myocardin by HDAC5 to inhibit cardiac hypertrophy induced by myocardin. Moreover, myocardin also can directly activate the mhrt transcription through binding to the CarG box. Thus, mhrt and myocardin form a regulation loop in the process of cardiac hypertrophy. This finding may play a positive role in revealing the complete mechanisms of cardiac hypertrophy.